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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Mitochondrial Handling Of Excess Ca2+ Is Substrate-Dependent With Implications For Reactive Oxygen Species Generation, Mohammed Aldakkak, David F. Stowe, Ranjan K. Dash, Amadou K.S. Camara
Mitochondrial Handling Of Excess Ca2+ Is Substrate-Dependent With Implications For Reactive Oxygen Species Generation, Mohammed Aldakkak, David F. Stowe, Ranjan K. Dash, Amadou K.S. Camara
Biomedical Engineering Faculty Research and Publications
The mitochondrial electron transport chain is the major source of reactive oxygen species (ROS) during cardiac ischemia. Several mechanisms modulate ROS production; one is mitochondrial Ca2+ uptake. Here we sought to elucidate the effects of extramitochondrial Ca2+ (e[Ca2+]) on ROS production (measured as H2O2 release) from complexes I and III. Mitochondria isolated from guinea pig hearts were preincubated with increasing concentrations of CaCl2 and then energized with the complex I substrate Na+ pyruvate or the complex II substrate Na+ succinate. Mitochondrial H2O2 release rates were assessed after …
Effect Of Arginine And Oscillatory Ca2+ On Vascular Response Mediated Via Nitric Oxide Signaling In Normal And Salt Sensitive Hypertensive Rat Mesenteric Arterioles, Tushar V. Gadkari
Effect Of Arginine And Oscillatory Ca2+ On Vascular Response Mediated Via Nitric Oxide Signaling In Normal And Salt Sensitive Hypertensive Rat Mesenteric Arterioles, Tushar V. Gadkari
FIU Electronic Theses and Dissertations
Hypertension, a major risk factor in the cardiovascular system, is characterized by an increase in the arterial blood pressure. High dietary sodium is linked to multiple cardiovascular disorders including hypertension. Salt sensitivity, a measure of how the blood pressure responds to salt intake is observed in more than 50% of the hypertension cases. Nitric Oxide (NO), as an endogenous vasodilator serves many important biological roles in the cardiovascular physiology including blood pressure regulation. The physiological concentrations for NO bioactivity are reported to be in 0-500 nM range. Notably, the vascular response to NO is highly regulated within a small concentration …