Biomedical Engineering and Bioengineering Commons^™

Semi-Interpenetrating Network Gelatin Fiber Sca Old For Oral Mucosal Delivery Of Insulin, Leyuan Xu

Theses and Dissertations

Common therapy for diabetes mellitus is subcutaneous administration of insulin that is subject to serious disadvantages, such as patient noncompliance and occasional hypoglycemia. Hence, oral administration of insulin could be more convenient and serve as a desired route. However, oral administration of insulin is severely limited by the low bioavailability of insulin through the gastrointestinal tract. In this study, a semi-interpenetrating network gelatin fiber scaffold (sIPN GF) was fabricated for oral mucosal delivery of insulin as an alternative route. This sIPN GF was engineered from an electrospun gelatin fiber scaffold (GF), which was further crosslinked with polyethylene glycol diacrylate (PEG-DA) …

A Regenerative Medicine Approach To Improved Tendon Healing And Repair, Grace Margaret Dion

All Theses

Surgical repair of torn tendons is a common orthopaedic procedure in the United States, with nearly 400,000 repairs occurring annually. Despite improvements in surgical techniques used to re-attach the tendon to its boney insertion, clinically successful outcomes amongst patients are variable and re-tear rates can be exceedingly high. The use of stem cells as an adjunct to surgical repair to aid in improving tendon healing and repair strength has gained much interest amongst the clinical community. Accordingly, many investigators have begun examining the ability of stem cells to differentiate into tenocytes using various methodologies including the application of growth factors …

Studies Of Functionalized Nanoparticles For Smart Self-Assembly And As Controlled Drug Delivery, Xiaochu Ding

Dissertations, Master's Theses and Master's Reports - Open

This dissertation is related to the studies of functionalized nanoparticles for self-assembly and as controlled drug delivery system. The whole topic is composed of two parts. In the first part, the research was conducted to design and synthesize a new type of ionic peptide-functionalized copolymer conjugates for self-assembly into nanoparticle fibers and 3D scaffolds with the ability of multi-drug loading and governing the release rate of each drug for tissue engineering. The self-assembly study confirmed that such peptide-functionalized amphiphilic copolymers underwent different self-assembly behavior. The bigger nanoparticles were more easily assembled into nanoparticle fibers and 3D scaffolds with larger pore …

Toward Directing Cell Fate: Carbon Nanotubes As Modulators Of Extracellular And Transporters Of Intracellular Cues, Qingsu Cheng

Theses and Dissertations

The unique properties of CNTs lead CNTs attractive in biological engineering applications. It is expected to use CNT based biomaterials for clinic use in the near future. CNTs can be used to tune cellular fate through bother extracellular pathway and intracellular pathway. CNT based biomaterials has been applied into bone, nerves, and cardiovascular system. There has also been progress in the use of CNTs in controlling cellular alignment, to enhance tissue regeneration, growth factor delivery and gene delivery.

Pluripotent stem cells (hPSCs) offer a promising tool in tissue engineering strategies, as their differentiated derivatives can be used to reconstruct most …