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Biomedical Engineering and Bioengineering Commons™
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- Keyword
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- Bone (2)
- Hip (2)
- ABAQUS (1)
- Amputee (1)
- Cam (1)
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- Climb (1)
- D-spacing (1)
- Device (1)
- FEA (1)
- Femoroacetabular Impingement (1)
- Finite Element Analysis (1)
- Implant (1)
- Mechanical properties (1)
- Nanoindentation (1)
- Osteoarthritis (1)
- Osteoporosis (1)
- Ovine (1)
- Pincer (1)
- Postmenopausal (1)
- Prosthesis (1)
- Prosthetic (1)
- SOST (1)
- Sclerostin (1)
- THA (1)
- Transfemoral (1)
- Viscoelastic (1)
Articles 1 - 5 of 5
Full-Text Articles in Biomedical Engineering and Bioengineering
Mechanical Properties Of Bone Due To Sost Expression: Nanoindentation Assessment Of Murine Femurs, Amir Rafie
Mechanical Properties Of Bone Due To Sost Expression: Nanoindentation Assessment Of Murine Femurs, Amir Rafie
Master's Theses
In the human genome, the SOST gene codes for a protein sclerostin. Sclerostin is an osteocyte-expressed negative regulator of bone formation. When the SOST gene is not coded, bone formation is reduced in individuals during skeletal maturation. This study utilizes nanoindentation methods to test for the mechanical properties of bones that both express and do not express the SOST gene. 100 transgenic murine femurs were obtained from Lawrence Livermore Labs in the form of 6 and 8 month SOST transgenic mice, 6 and 12 month SOST knockout mice, and wild type control littermates for each of the 4 age groups. …
Finite Element Analysis And Validation Of Hip Joints With The Main Types Of Femoroacetabular Impingement, Kevin Lucas Mitchell
Finite Element Analysis And Validation Of Hip Joints With The Main Types Of Femoroacetabular Impingement, Kevin Lucas Mitchell
Master's Theses
Current research suggests that femoroacetabular impingement can be a cause of osteoarthritis. Femoroacetabular impingement is a condition that can affect both the femur and the pelvis of an individual. Femoroacetabular impingement can cause damage to the hip joint and its surrounding tissues. The articular cartilage and the labrum are both affected by this condition. A cam impingement is where a bony protrusion develops at the femoral head/neck junction. A pincer impingement is where a bony protrusion develops at the acetabular rim. Often, patients are seen with a combination of both impingements. The main goal of this study was to computationally …
The Effects Of Variation In Collagen D-Spacing On Compact Bone Viscoelasticity: A Finite Element Analysis, Miguel A. Mendoza
The Effects Of Variation In Collagen D-Spacing On Compact Bone Viscoelasticity: A Finite Element Analysis, Miguel A. Mendoza
Master's Theses
The D-spacing that is characteristic of collagen and its structural arrangement was previously thought to be a constant value. Much research is revealing that it is actually a distribution of values in biological tissues. Recent ovine experimentation has also shown that the D-spacing distribution is significantly altered following estrogen depletion. While ewes contain some major biological differences between their human counterparts, they are an economical and robust large animal model for postmenopausal osteoporosis. So, the exploration of the possible implications that D-spacing has on the mechanical properties of the whole bone utilizing animal models and computational methods is warranted. Six …
Design And Development Of A Stair Ascension Assistive Device For Transfemoral Amputees, Casey Michael Barbarino
Design And Development Of A Stair Ascension Assistive Device For Transfemoral Amputees, Casey Michael Barbarino
Master's Theses
Transfemoral amputees around the world experience increased difficulty in climbing stairs due to lack of muscle, balance, and other factors. The loss of a lower limb greatly diminishes the amount of natural force generation provided that is necessary to propel oneself up stairs. This study investigated possible solutions to the problem of stair ascension for transfemoral amputees by the means of designing and developing an externally attachable device to a prosthesis. The number of amputations from military service has greatly increased since 2008, which shows there is a clear need for assistive devices (Wenke, Krueger, & Ficke, 2012). With the …
Modeling The Zimmer Fitmore And Ml Taper Implantation, Tyler Kazuo Franklin
Modeling The Zimmer Fitmore And Ml Taper Implantation, Tyler Kazuo Franklin
Master's Theses
With more young adults requiring total hip
arthroplasties the need for bone saving implants becomes
more important. The Zimmer Fitmore is a new bone saving
implant that utilizes an implantation technique that
reduces the damage to the muscle tissue allowing for
patients to have a short recovery time as well as a new
design that allows it to rest on the medial cortex. There
has been anecdotal evidence that this device leads to early
revision within six months of implantation due to failures
occurring in the medial cortex. The main goal of this
study was to computationally model the Zimmer …