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Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
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- Anti-bacterial (1)
- Bioactive (1)
- Bioinert (1)
- Bone Cement (1)
- Chondroitin sulfate proteoglycans (1)
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- Chondroitinase ABC (1)
- Decomposition (1)
- Diesel fuel (1)
- Drug Delivery (1)
- Micelles (1)
- Multivariate regression (1)
- Nanoparticles (1)
- Organotypic culture (1)
- Polysaccharides (1)
- Radiopaque (1)
- Raman spectroscopy (1)
- Rheumatoid Arthritis (1)
- Solid deposits (1)
- Spinal cord injury (1)
- Strontium-substituted hydroxyapatite (1)
- Supercritical (1)
- Thermal stability (1)
- Publication
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Articles 1 - 5 of 5
Full-Text Articles in Biomedical Engineering and Bioengineering
Raman Spectroscopic Investigation Of Chondroitinase Abc Treatment After Spinal Cord Injury In An Organotypic Model, Shane Ruberto
Raman Spectroscopic Investigation Of Chondroitinase Abc Treatment After Spinal Cord Injury In An Organotypic Model, Shane Ruberto
Theses - ALL
This study investigated (1) the ability of an organotypic model of spinal cord injury (SCI) to recapitulate significant pathobiological events of in vivo SCI from a Raman spectroscopic perspective, and (2) the Raman spectroscopic effects of chondroitinase ABC (cABC) treatment on said model of SCI. Tissue from mouse spinal cords was excised, sectioned, and placed into culture, before being systematically injured to induce trauma. Cultures with and without cABC treatment were assessed using Raman spectroscopy at varying times post-injury. We demonstrate that Raman spectral phenomena characteristic of SCI can be observed using an organotypic model. By comparing these phenomena with …
Polysaccharide-Based Nanocarriers For Improved Drug Delivery, Nan Zhang
Polysaccharide-Based Nanocarriers For Improved Drug Delivery, Nan Zhang
Dissertations - ALL
The field of drug delivery has provided a solution to the limited efficacy and high toxicity of many drugs. Nano-sized drug carriers are popular because their size allows for selective accumulation in the diseased area. Polysaccharides are non-toxic and biodegradable natural polymers that can serve as the basis for these nano-sized carriers. Polysialic acid (PSA) is such a polysaccharide with strong hydrophilicity that may reduce uptake by the reticuloendothelial system and prolong drug circulation. In this study, we developed PSA-based nanocarriers, specifically micelles and nanoparticles, for improved drug delivery with improved efficacy and minimized toxicity. PSA-based micelle systems were developed …
Improving Bioactivity And The Anti-Bacterial Properties Of Two-Solution Bone Cement Containing Cross-Linked Polymethylmethacrylate (Pmma) Nanospheres (Η-Tsbc), Shailly Jariwala
Improving Bioactivity And The Anti-Bacterial Properties Of Two-Solution Bone Cement Containing Cross-Linked Polymethylmethacrylate (Pmma) Nanospheres (Η-Tsbc), Shailly Jariwala
Biomedical and Chemical Engineering - Dissertations
The high viscosity standard two-solution bone cements (STSBC) developed in our laboratory exhibits several advantages over other commercial powder-liquid cement formulations. However, the high monomer concentration, viscosity, and exothermal temperature are considered a major limitation to the use of this material. Modified two-solution cements containing cross-linked polymethylmethacrylate (PMMA) nanospheres (η-TSBC), as part of the polymer phase, were fabricated as the first step for optimization of cement viscosity for application of the material in the treatment of vertebral compression fractures using vertebroplasty (VP) and kyphoplasty (KP). The η-TSBC exhibited reduced viscosity, lower polymerization exotherm, and residual monomer in comparison to STSBC. …
Controlling Bacterial Persister Cells With Low Level Electric Currents, Henry Lars Peterson
Controlling Bacterial Persister Cells With Low Level Electric Currents, Henry Lars Peterson
Honors Capstone Projects - All
Bacterial persister cells present a growing concern as they inherit the ability to tolerate high concentrations of antibiotics and repopulate after an antibiotic treatment leading to chronic diseases. Pseudomonas aeruginosa causes many human infections including skin infections and those associated with burn injuries, and implanted medical devices, and are associated with Cystic Fibrosis. Recently, the Ren Lab developed a novel approach to eliminate persister cells of P. aeruginosa, including those in biofilms, using low level electric currents. To evaluate the safety of this method and to better understand how the underlying elements, this study focused on the cytotoxicity of …
Thermal Stability And Decomposition Of Diesel Fuel Under Subcritical And Supercritical Conditions, Ronghong Lin, Lawrence L. Tavlarides
Thermal Stability And Decomposition Of Diesel Fuel Under Subcritical And Supercritical Conditions, Ronghong Lin, Lawrence L. Tavlarides
Biomedical and Chemical Engineering - All Scholarship
A novel concept of clean diesel combustion using supercritical fluids is proposed and being investigated to address some key challenges encountered in the fuel and transportation sector. The core of this concept is to inject diesel fuel (DF) in the supercritical state to achieve clean, high-efficient combustion in diesel engines. Among other challenging issues that must be addressed for the implementation of this new concept is the thermal stability of DF and the potential decomposition and solid deposit formation under engine conditions. In this work, thermal stability of DF was experimentally evaluated under subcritical and supercritical conditions in both static …