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Full-Text Articles in Biomedical Engineering and Bioengineering
White Matter Structural Connectivity Is Associated With Sensorimotor Function In Stroke Survivors, Benjamin Kalinosky, Sheila M. Schindler-Ivens, Brian D. Schmit
White Matter Structural Connectivity Is Associated With Sensorimotor Function In Stroke Survivors, Benjamin Kalinosky, Sheila M. Schindler-Ivens, Brian D. Schmit
Biomedical Engineering Faculty Research and Publications
Purpose
Diffusion tensor imaging (DTI) provides functionally relevant information about white matter structure. Local anatomical connectivity information combined with fractional anisotropy (FA) and mean diffusivity (MD) may predict functional outcomes in stroke survivors. Imaging methods for predicting functional outcomes in stroke survivors are not well established. This work uses DTI to objectively assess the effects of a stroke lesion on white matter structure and sensorimotor function.
Methods
A voxel-based approach is introduced to assess a stroke lesion's global impact on motor function. Anatomical T1-weighted and diffusion tensor images of the brain were acquired for nineteen subjects (10 post-stroke and 9 …