Biomedical Engineering and Bioengineering Commons^™

Image Skeletal Muscle Progenitors In Situ To Investigate How The Ecm Composition Regulates Musculoskeletal Assembly, Andrew L. Schilb, Sarah Calve

The Summer Undergraduate Research Fellowship (SURF) Symposium

Regenerative medicine has difficulty with the human body’s inability to functionally repair tissues lost as a result of disease or serious accident. Through tissue engineering, there has been development of various scaffolding with the purpose of enhancing skeletal muscle regrowth and functionality. The scaffolds are typically constructed from artificial polymers or decellularized extracellular matrix (ECM) that mimics adult tissue. These standardized scaffolds are hindered though by the host since tissue engineers have not taken into account of how the composition musculoskeletal ECM during tissue repair is dramatically different than that of a homeostatic adult. Now green fluorescent protein positive (GFP+) …