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Full-Text Articles in Biomedical Engineering and Bioengineering

Novel Model Of Cerebrospinal Fluid Dynamics Based On Hemodynamically Driven Cyclic Brain Compliance Variation, Bruno A. Mantilla Aug 2007

Novel Model Of Cerebrospinal Fluid Dynamics Based On Hemodynamically Driven Cyclic Brain Compliance Variation, Bruno A. Mantilla

Dissertations

This study provides a novel explanation for the CerebrQ-Spinal Fluid (CSF) flow pattern observed in phase contrast cine-MRJ studies. CSF dynamics has been traditionally explained as a bulk flow from the site of production to the site of absorption. Studies done with phase contrast cine-MRI show a more complex CSF movement, that is not explainable by the bulk flow paradigm. This study describes a mechanism explaining how the energy delivered by the heart in each cycle is responsible not only for the blood flow, but also for the CSF circulation. This mechanism is based on a cyclic variation of brain …


Performance Characteristics Of A Therapeutic Ultrasound Wire Waveguide, Graham Gavin, Garrett Mcguinness, Finbar Dolan, M.S. Hashmi Mar 2007

Performance Characteristics Of A Therapeutic Ultrasound Wire Waveguide, Graham Gavin, Garrett Mcguinness, Finbar Dolan, M.S. Hashmi

Articles

Therapeutic ultrasound angioplasty has been investigated, clinically, by a number of researchers and represents a potentially promising therapy for the treatment of atherosclerotic lesions. To date, there has been no detailed analysis of the effect of mechanical design parameters, such as wire geometry or damping characteristics, on wire waveguide performance. An apparatus capable of delivering therapeutic ultrasound down small diameter nickel–titanium (NiTi) wire waveguides is described. The output peak-to-peak (p–p) displacements at the distal tip of a 1.0mm diameter waveguide were measured experimentally, by means of an optical microscope and image analysis software. The output was measured for a range …


Development And Validation Of A Computational Musculoskeletal Model Of The Elbow Joint, Justin Paul Fisk Jan 2007

Development And Validation Of A Computational Musculoskeletal Model Of The Elbow Joint, Justin Paul Fisk

Theses and Dissertations

Musculoskeletal computational modeling is a versatile and effective tool which may be used to study joint mechanics, examine muscle and ligament function, and simulate surgical reconstructive procedures. While injury to the elbow joint can be significantly debilitating, questions still remain regarding its normal, pathologic, and repaired behavior. Biomechanical models of the elbow have been developed, but all have assumed fixed joint axes of rotation and ignored the effects of ligaments. Therefore, the objective of this thesis was to develop and validate a computational model of the elbow joint whereby joint kinematics are dictated by three-dimensional bony geometry contact, ligamentous constraints, …