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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Lung Circulation Modeling: Status And Prospect, Anne V. Clough, Said H. Audi, Robert C. Molthen, Gary S. Krenz
Lung Circulation Modeling: Status And Prospect, Anne V. Clough, Said H. Audi, Robert C. Molthen, Gary S. Krenz
Biomedical Engineering Faculty Research and Publications
Mathematical modeling has been used to interpret anatomical and physiological data obtained from metabolic and hemodynamic studies aimed at investigating structure-function relationships in the vasculature of the lung, and how these relationships are affected by lung injury and disease. The indicator dilution method was used to study the activity of redox processes within the lung. A steady-state model of the data was constructed and used to show that pulmonary endothelial cells may play an important role in reducing redox active compounds and that those reduction rates can be altered with oxidative stress induced by exposure to high oxygen environments. In …
Design Of Near-Optimal Waveforms For Chest And Abdominal Compression And Decompression In Cpr Using Computer-Simulated Evolution, Charles F. Babbs
Design Of Near-Optimal Waveforms For Chest And Abdominal Compression And Decompression In Cpr Using Computer-Simulated Evolution, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Publications
Objective: To discover design principles underlying the optimal waveforms for external chest and abdominal compression and decompression during cardiac arrest and CPR. Method: A 14-compartment mathematical model of the human cardiopulmonary system is used to test successive generations of randomly mutated external compression waveforms during cardiac arrest and resuscitation. Mutated waveforms that produced superior mean perfusion pressure became parents for the next generation. Selection was based upon either systemic perfusion pressure (SPP=thoracic aortic minus right atrial pressure) or upon coronary perfusion pressure (CPP=thoracic aortic pressure minus myocardial wall pressure). After simulations of 64,414 individual CPR episodes, 40 highly evolved waveforms …