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Myocardial Recovery From Ischemia Is Impaired In Cd36-Null Mice And Restored By Myocyte Cd36 Expression Or Medium-Chain Fatty Acids., Glenn Gaudette, H Irie, I Krukenkamp, J Brinkmann, A Saltman, W Jou, J Glatz, N Abumrad, A Ibrahimi

Glenn R. Gaudette

Long-chain fatty acid uptake, which provides a large part of myocardial energy, is impaired in human and murine hearts deficient in the membrane fatty acid translocase, FAT/CD36. We examined myocardial function in CD36-null mice using the working heart. Fatty acid oxidation and stores of glycogen, triglycerides, and ATP were reduced in CD36-deficient hearts and were restored to WT levels by rescue of myocyte CD36. Under normal perfusion conditions, CD36-null hearts had similar cardiac outputs and end-diastolic pressures as WT or transgenic hearts. After 6 min of ischemia, cardiac output decreased by 41% and end diastolic pressure tripled for CD36-null hearts, …