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Full-Text Articles in Biomedical Engineering and Bioengineering
Stiffness Of Measurement System And Significant Figures Of Displacement Which Are Required To Interpret Adhesional Force Curves, Nancy Burnham, Kunio Takahashi, Hubert Pollock, Tadao Onzawa
Stiffness Of Measurement System And Significant Figures Of Displacement Which Are Required To Interpret Adhesional Force Curves, Nancy Burnham, Kunio Takahashi, Hubert Pollock, Tadao Onzawa
Nancy A. Burnham
Force curves obtained from an elastic contact theory are shown and compared with experimental results. In the elastic contact theory, a pin-on-disk contact is assumed and the following interaction are taken into consideration; (i) elastic deformation, (ii) the specific energy of adhesion in the area of the contact, which is expressed as the difference between the surface energies and the interface energy, (iii) the long-range interaction outside the area of contact, assuming the additivity of the Lennard-Jones type potential, and (iv) another elastic term for the measurement system such as the cantilever stiffness of an atomic force microscope (AFM). In …
Detachment Of Human Endothelial Cells Under Flow From Wettability Gradient Surfaces With Different Functional Groups, T. G. Ruardy, H. E. Moorlag, J. M. Schakenraad, H. C. Van Der Mei, H. J. Busscher
Detachment Of Human Endothelial Cells Under Flow From Wettability Gradient Surfaces With Different Functional Groups, T. G. Ruardy, H. E. Moorlag, J. M. Schakenraad, H. C. Van Der Mei, H. J. Busscher
Cells and Materials
In this study, the position bound adhesion, spreading and detachment under flow of human umbilical cord endothelial cells (HUVEC) was studied on a dichlorodimethylsilane (DDS), dimethylocta-decylchlorosilane (DOCS) and tridecafluor-1,1,2,2-tetrahydrooctyl-1-dimethylchlorosilane (TFCS) wettability gradient on glass. Gradient surfaces were prepared by the diffusion method and characterized by the Wilhelmy plate technique for their wettability and by X-ray photoelectron spectroscopy (XPS) for their chemical composition. Quantitative analysis of the cellular response on the wettability gradient surfaces showed that the position bound cellular response was influenced by wettability for each type of gradient in a different way. On DDS-wettability gradients, cells withstood flow best …