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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Macrophage Response To Polymethylmethacrylate Particles, Stephen M. Horowtiz
Macrophage Response To Polymethylmethacrylate Particles, Stephen M. Horowtiz
Cells and Materials
This paper reviews studies performed by this laboratory involving the macrophage response to implant particles. Through the development of a tissue culture model, we have studied the events which occur following macrophage phagocytosis of bone cement particles, the released mediators and cell interactions which may ultimately lead to bone resorption, and the inhibition of this process with the use of pharmaceutical agents. This is divided into the following sections: Histologic response of macrophages to cement particles I toxicity I and mediator release, the effects of particle size and composition on mediator release by macrophages, macrophage I osteoblast interactions, macrophage I …
Biological Response To Particulate Debris: In Vitro And In Vivo Studies, A. S. Shanbhag, J. E. Dowd, J. J. Jacobs, D. M. Tramaglini, T. T. Glant, J. Black, H. E. Rubash
Biological Response To Particulate Debris: In Vitro And In Vivo Studies, A. S. Shanbhag, J. E. Dowd, J. J. Jacobs, D. M. Tramaglini, T. T. Glant, J. Black, H. E. Rubash
Cells and Materials
In this study, we compared the results of a human monocyte in vitro model and a canine in vivo model, to evaluate the response to different types of particulate wear debris. Both the in vitro and in vivo studies demonstrated that titanium-6 aluminum-4 vanadium (TiAIV), ultrahigh molecular weight polyethylene (UHMWPE) and other particulate wear debris are stimulatory to macrophages and elicit release of several identifiable mediators involved in periprosthetic inflammation and bone resorption. Further, in the in vivo studies, these same particles initiated the formation of interfacial membranes which were histologically and biochemically similar to those seen in clinically failed …