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Full-Text Articles in Biomedical Engineering and Bioengineering
Human Ipsc Tissue-Engineered Cartilage For Disease Modeling Of Skeletal Dysplasia-Causing Trpv4 Mutations, Amanda R. Dicks
Human Ipsc Tissue-Engineered Cartilage For Disease Modeling Of Skeletal Dysplasia-Causing Trpv4 Mutations, Amanda R. Dicks
McKelvey School of Engineering Theses & Dissertations
Cartilage is essential to joint development and function. However, there is a variety of cartilage diseases, ranging from developmental (e.g., skeletal dysplasias) to degenerative (e.g., arthritis), in which treatments and therapeutics are lacking. For example, specific point mutations in the ion channel transient receptor potential vanilloid 4 (TRPV4) prevent proper joint development, leading to mild brachyolmia and severe, neonatally lethal metatropic dysplasia. Tissue-engineered cartilage offers an opportunity to elucidate the underlying mechanisms of these cartilage diseases for the development of treatments. Human induced pluripotent stem cells (hiPSCs) are an improved cell source option for cartilage tissue engineering given their minimal …
K-Wire Differentiation, Oluwadamilola Oluwadara, Lillian Maresco, Eunjung Lee, Michelle De Leon
K-Wire Differentiation, Oluwadamilola Oluwadara, Lillian Maresco, Eunjung Lee, Michelle De Leon
Honors Theses
Kirschner Pins, known as K-wires, are smooth sharp stainless steel pins used in the field of orthopedics to stabilize bone fracture fragments in their correct position until they have fully healed. K-wires are most commonly used for comminuted metaphyseal fractures of the long bones, and fractures of smaller bones such as the phalanges. The wires are inserted into bone via a drill and the ends of the wire are bent and left outside of the body for easy removal once the bone has healed. The surgeon uses x-ray images to guide K-wire insertion, ensure proper internal alignment, and determine if …