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Full-Text Articles in Biomedical Engineering and Bioengineering
Stirred Suspension Bioreactor Differentiation Of Human Mesenchymal Stem Cells Into Smooth Muscle Cells, Chris Slavin
Stirred Suspension Bioreactor Differentiation Of Human Mesenchymal Stem Cells Into Smooth Muscle Cells, Chris Slavin
Biomedical Engineering Undergraduate Honors Theses
Human mesenchymal stem cells (hMSCs) are a promising candidate for cellular therapies due to their multipotency, self-renewal capacity, and immunomodulatory properties. However, their isolation is a difficult and potentially painful process with very low yield, and traditional static mammalian cell culture techniques are too slow and expensive for large scale growth and differentiation of stem cells to be practical. Current research is focused on improving methods for cultivating hMSCs in stirred suspension bioreactors (SSBs), but little work has been done with regard to their differentiation in dynamic conditions such as those in SSBs. Differentiation at a large scale would increase …