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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Study Of The Stability Of Heparin/Collagen Layer-By-Layer Coatings, Hector M. Apodaca Reyes
Study Of The Stability Of Heparin/Collagen Layer-By-Layer Coatings, Hector M. Apodaca Reyes
Chemical Engineering Undergraduate Honors Theses
Pairing heparin with collagen-based medical implants has opened a whole new area of research for enhancing the desired effect of current implants. In fact, heparin (HEP) and collagen (COL) layer-by-layer (LbL) coatings have shown impressive results in forming polyelectrolyte multilayers. It has been already seen on skin grafts, nerve guide conduits (NGCs), and drug delivery devices yielding promising results. Due to being a simple, cost-efficient, and versatile option to fabricate thin biomimetic films, this self-assembly technique is one of the most effective methods to immobilize extracellular matrix (collagen and heparin) onto medical devices and implants. Even though previous studies have …
Development Of Hybrid Coating Materials To Improve The Success Of Titanium Implants, Zach Gouveia
Development Of Hybrid Coating Materials To Improve The Success Of Titanium Implants, Zach Gouveia
Electronic Thesis and Dissertation Repository
While titanium (Ti) and its alloys have become ubiquitous within implantology as materials to restore or augment the function of human tissues, their success is plagued by complications associated with infection and aseptic implant loosening. These two risks account for the majority of implant failures in the clinic and limit the long-term success of titanium implants in vivo. Therefore, this thesis describes the development of robust multifunctional class II organic-inorganic hybrid coating materials for titanium implants that could be used to effectively target both complications, concurrently. During this master’s work, two different coating systems were examined. First, class II …
Design Of Tissue-Specific Cellular Microenvironments For Adipose-Derived Stromal Cell Culture And Delivery, Arthi Shridhar
Design Of Tissue-Specific Cellular Microenvironments For Adipose-Derived Stromal Cell Culture And Delivery, Arthi Shridhar
Electronic Thesis and Dissertation Repository
The development of in vitro cell culture models that investigate tissue-specific effects of the extracellular matrix (ECM) on stem/progenitor cell lineage-commitment can contribute towards the design of improved cell delivery strategies. This thesis developed processing methods that conserved ECM bioactivity to generate well-characterized 2- and 3-D culture platforms that facilitated the evaluation of ECM composition on the adipogenic and osteogenic differentiation of human adipose-derived stromal cells (ASCs). Initial work compared α-amylase and pepsin digestion as methods to fabricate ECM coatings. The effects of enzyme processing and ECM composition were explored using human decellularized adipose tissue (DAT) and bovine tendon collagen …