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Full-Text Articles in Biomedical Engineering and Bioengineering
Development Of Biomechanical Analysis Techniques For Fatigue Of Transtibial Prosthetic Socket And Pylon Interactions, Thomas Z. Sudbury
Development Of Biomechanical Analysis Techniques For Fatigue Of Transtibial Prosthetic Socket And Pylon Interactions, Thomas Z. Sudbury
Honors Theses
The lack of formal, engineering based information is prevalent in the prosthetic industry. Currently, very few prosthetic manufacturing companies can definitively tell their patients how long their products will last. Because of this lack of information, many amputee patients will experience failure of their transtibial prosthetic device during daily activities. One such failure occurs from the fatigue of everyday use. Fatigue failures originate from the repeated application of certain loading conditions. These repeated loads usually occur for millions of cycles before a transtibial prosthetic catastrophically fails. The purpose of this study is to develop a testing procedure and apparatus that …
Potential Optimal Gait Performance Of Mauch S-N-S Prosthetic Knee Configurations As Predicted By Dynamic Modeling, Chih-Hao Chien
Potential Optimal Gait Performance Of Mauch S-N-S Prosthetic Knee Configurations As Predicted By Dynamic Modeling, Chih-Hao Chien
ETD Archive
Patients with prosthetic legs routinely suffer from abnormal gait patterns which can cause health issues and eventually lower the quality of their lives. Despite the half-century advance in the technology of prosthetic knees, from the purely mechanical to microprocessor controlled systems, patient testing suggests that very little progress has been made in the quality of the kinetics and kinematics of amputee gait. Moreover, the cost of microprocessor controlled prosthetic knees may be 10 times more than the purely mechanical knees. While prosthetic knees have become more complex and expensive, it is not proven that the prosthetic knee is a central …
Design Of Recombinant Tenebrio Molitor Antifreeze Protein For Purification Using Elastin-Like Polypeptide Tag, Joongseok Oh
Design Of Recombinant Tenebrio Molitor Antifreeze Protein For Purification Using Elastin-Like Polypeptide Tag, Joongseok Oh
ETD Archive
Fusion protein technologies can aid to improve solubility of recombinant protein from microorganisms and help recombinant protein purification. Elastin-like polypeptides (ELP) as a fusion tag can be utilized to facilitate the purification of recombinant proteins because ELP can provide its thermally responsive behavior to ELP tagged proteins. An ELP tag can be used as the purification carrier through inverse transition cycling (ITC), which is a simple and non chromatographic separation process. The purification through ITC can reduce cost and can be quickly performed compared to other purification methods. However, we further considered ELP tag removal because it may possibly hinder …
Evolutionary Optimization Of Atrial Fibrillation Diagnostic Algorithms, Aref Smiley
Evolutionary Optimization Of Atrial Fibrillation Diagnostic Algorithms, Aref Smiley
ETD Archive
The goal of this research is to introduce an improved method for detecting atrial fibrillation (AF). The foundation of our algorithm is the irregularity of the RR intervals in the electrocardiogram (ECG) signal, and their correlation with AF. Three statistical techniques, including root mean squares of successive differences (RMSSD), turning points ratio (TPR), and Shannon entropy (SE), are used to detect RR interval irregularity. We use the Massachusetts Institution of Technology / Beth Israel Hospital (MIT-BIH) atrial fibrillation databases and their annotations to tune the parameters of the statistical methods by biogeography-based optimization (BBO), which is an evolutionary optimization algorithm. …