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Articles 1 - 11 of 11
Full-Text Articles in Biomedical Engineering and Bioengineering
Expression Systems For Synthetic Spider Silk Protein Production, Michaela R. Hugie
Expression Systems For Synthetic Spider Silk Protein Production, Michaela R. Hugie
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Spider silk is a biodegradable and biocompatible natural material that is stronger than steel and more elastic than nylon. These properties make spider silk a desirable material for many commercial products, ranging from textiles to biomedical materials. Due to spiders’ cannibalistic and territorial nature it is impossible to farm them to produce spider silk at a high enough yield to meet product demands. Therefore, a bioengineered synthetic process is necessary to produce spider silk. Synthetic spider silk has been produced in bacteria, goats, yeast, plants, mammalian cells and silkworms, but none of these processes provided a commercially viable yield or …
Adipose Tissue Engineering: A Therapeutic Strategy For The Treatment Of Obesity And Glucose Intolerance, Michael A. Hendley
Adipose Tissue Engineering: A Therapeutic Strategy For The Treatment Of Obesity And Glucose Intolerance, Michael A. Hendley
Theses and Dissertations
Despite available treatment options, the number of people afflicted by type 2 diabetes has steadily risen for decades. Nearly 90% of the diabetic population also suffers from obesity and the link between the two diseases is undeniable. Characterized by rapid expansion of the adipose tissue and improper lipid storage, the mishandling of lipids by adipose tissue promotes the diabetic state. Excess lipids, unable to be properly stored, build up in peripheral tissues promoting insulin resistance and type 2 diabetes. Therapeutic strategies designed to address adipose tissue lipid handling could represent a promising treatment strategy for obesity associated type 2 diabetes. …
Design, Construction And Application Of A Home-Built, Two-Photon Microscope, William P. Breeding
Design, Construction And Application Of A Home-Built, Two-Photon Microscope, William P. Breeding
Electronic Theses and Dissertations
Two-photon microscopy (TPM) is a powerful, versatile imaging modality for the study of biological systems. This thesis overviews the relevant physics involved in TPM, design considerations and process of constructing a home-built, two-photon microscope, and provides a set of procedures to operate the system. Furthermore, this work explores several applications of TPM through the study of single-cell metabolism and imaging the cellular-material interface. Explored in particular depth was the imaging of cellulose nanofiber (CNF) materials, with the goal of understanding the three-dimensional nature of fibroblast cell growth when embedded within the materials. This work uncovered several optical properties of CNF, …
On-Demand Label Production, Robert A. Zimmerman
On-Demand Label Production, Robert A. Zimmerman
Master's Theses
The production and approval process for the various labels used in clinical trials wastes significant time and resources through the need to outsource label production or rely on large reams of pre-cut label stock for each revision throughout the process. An in-house, on-demand label printing and cutting system is a potential remedy to this waste. Previous work by Cheadle et al. resulted in a functional electomechanical prototype of the label cutting aspect of this research, capable of rudimentary linear cuts. In this continued research, emphasis was placed on improved label cutting capabilities and creating PC control software for label design. …
Chondroitin Sulfate Hydrogels For Total Wound Care Devices, Tushar Goswami
Chondroitin Sulfate Hydrogels For Total Wound Care Devices, Tushar Goswami
Browse all Theses and Dissertations
Chondroitin sulfate (CS) is a naturally occurring bio-polymer found in areas of high cartilage in mammals. In directed applications, such as hydrogels, CS can be used to impact keratinocyte growth cycles. In this work, CS based hydrogels were utilized to accelerate wound healing and, in conjunction with a graphene sensor, monitor wound fluid pH. The hydrogels were cast onto a graphene field effect transistor (GFET) to obtain the benefits of the hydrogel wound healing capabilities, while also utilizing the pH sensitivity of the graphene. Results showed that the hydrogel caused a fivefold increase in cell size over the course of …
Development And Exploration Of A Z-Shaped Foot And Ankle Internal Fixation Plate, Rhaz Shaghaghi Paul, Ian Hames, Sean Rich
Development And Exploration Of A Z-Shaped Foot And Ankle Internal Fixation Plate, Rhaz Shaghaghi Paul, Ian Hames, Sean Rich
Williams Honors College, Honors Research Projects
This paper will detail the design process of developing a Z-shaped foot and ankle internal fixation plating system. Group 6: Plates for the Sole was made up of 5 team members, who worked together to accommodate their client’s request to complete a biomechanical analysis of a Z-Plate design and a construct a prototype. The Z-Plate’s purpose is to provide podiatrists with a new solution that can fit nicely on the small, irregular bones of the foot, while also remaining strong enough to withstand the forces and torques of the foot.
Project "Auxilia" - Jaiden's Prosthetic Arm, Christopher Halley, Lindsay Jaros, Autumn Young
Project "Auxilia" - Jaiden's Prosthetic Arm, Christopher Halley, Lindsay Jaros, Autumn Young
Williams Honors College, Honors Research Projects
The main objective of this project was to create a prosthetic arm for a 15 year old boy named Jaiden Foden. Jaiden was born with only one fully developed limb as a result of a genetic disorder, Hanhart Syndrome II. His right arm becomes a residual limb below the elbow, but has two fingers which act in a “claw-like” movement. Jaiden’s left arm becomes a residual limb above the elbow, and his left leg becomes a residual limb above the knee. The goal of the arm was to increase Jaiden’s overall independence and to help in completing daily tasks, such …
Easy Adjustable Protective Helmet, Ryan Balash
Easy Adjustable Protective Helmet, Ryan Balash
Williams Honors College, Honors Research Projects
Akron Children’s Hospital and The University of Akron’s Biomedical Engineering Design Team Engineering Forward have paired together to improve medical adapted helmets for post-operative and disabled patients. An issue is the helmets are only produced in a couple of sizes. Also, it is a tedious process to constantly adjust the pressure on the patient’s cranium within a trial-and-error process. Engineering Forward plans to improve the effectiveness of this helmet by creating an adjustable helmet that can read the pressure on a patient’s head. The caregiver can then make the necessary adjustments to the helmet to accommodate the patient. Documents of …
Mechanical Stresses On Nasal Mucosa Using Nose-On-Chip Model, Zachary Edward Brooks
Mechanical Stresses On Nasal Mucosa Using Nose-On-Chip Model, Zachary Edward Brooks
Browse all Theses and Dissertations
The objective of this research was to design and fabricate a nose-on-chip device and bi-directional airflow system that models flow within the nasal cavity to investigate how airflow induced mechanical stresses impact nasal secretion rates and cytoskeletal remodeling. This research hypothesizes that the airflow induced shear stresses on the nasal mucosa will influence mucus production and the cytoskeleton of the cells. The RPMI 2650 cell line was used to model the nasal mucosa. The system was used to replicate the wall shear stresses (WSS) and wall shear forces (WSF) present in the anterior region of the nose. The WSS and …
Monitoring Cerebral Functional Response Using Scmos-Based High Density Near Infrared Spectroscopic Imaging, Dharminder Singh Langri
Monitoring Cerebral Functional Response Using Scmos-Based High Density Near Infrared Spectroscopic Imaging, Dharminder Singh Langri
Browse all Theses and Dissertations
Neurovascular coupling is an important concept that indicates the direct link between neuronal electrical firing with the vascular hemodynamic changes. Functional Near Infrared Spectroscopy (fNIRS) can measure changes in cerebral vascular parameters of oxy-hemoglobin and deoxyhemoglobin concentrations and thus can provide neuronal activity through neurovascular coupling. Currently many commercial fNIRS devices are available, but they are limited by the number of channels (usually having only 8 detectors), which can limit the sensitivity, contrast, and resolution of imaging. High-density imaging can improve sensitivity, contrast, and resolution by providing many measurements and averaging the signals originating from the target cerebral focus area …
Characterization Of In-Vivo Damage In Implantable Cardiac Devices And The Lead Residual Properties, Anmar Mahdi Salih
Characterization Of In-Vivo Damage In Implantable Cardiac Devices And The Lead Residual Properties, Anmar Mahdi Salih
Browse all Theses and Dissertations
Approximately, 92.1 million patients in the US suffer from cardiovascular diseases with an estimated healthcare cost of over $300 billion; out of which at least one million patients have Cardiac Implantable Electronics Devices (CIED). CIED represented by pacemakers, Implantable Cardioversion Defibrillator (ICD), and Cardiac Resynchronization Therapy (CRT) are exposed to in-vivo damage. These damages are complex and composed on multiple levels and present challenges while assessing their combined extent. Since 2004, more than one hundred recalls were reported for cardiac devices. ICD devices had the majority with 40.8% recalls, pacemaker recall percentage was 14.5%, CRT recall percentage was12.7%, leads recalls …