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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 9 of 9
Full-Text Articles in Biomedical Engineering and Bioengineering
Acetylation Profiles Of Histone And Non-Histone Proteins In Breast Cancer, Alla Karpova
Acetylation Profiles Of Histone And Non-Histone Proteins In Breast Cancer, Alla Karpova
McKelvey School of Engineering Theses & Dissertations
This study evaluates the impact of protein acetylation on breast cancer gene expression and the regulation of metabolism. Acetylation is the second abundant post-translational modification after phosphorylation, regulating protein activity and function. The alterations in acetylation of both histone and non-histone proteins is known to be related to many human diseases, including cancer. Acetylation and deacetylation of histones is closely associated with the regulation of gene expression, while acetylation of non-histone proteins may have a broad effect on major cellular processes, such as proliferation, metabolism, cell cycle and apoptosis, imbalanced regulation of which is essential for cancer development. Therefore, it’s …
A Study Of Scalability And Cost-Effectiveness Of Large-Scale Scientific Applications Over Heterogeneous Computing Environment, Arghya K. Das
A Study Of Scalability And Cost-Effectiveness Of Large-Scale Scientific Applications Over Heterogeneous Computing Environment, Arghya K. Das
LSU Doctoral Dissertations
Recent advances in large-scale experimental facilities ushered in an era of data-driven science. These large-scale data increase the opportunity to answer many fundamental questions in basic science. However, these data pose new challenges to the scientific community in terms of their optimal processing and transfer. Consequently, scientists are in dire need of robust high performance computing (HPC) solutions that can scale with terabytes of data.
In this thesis, I address the challenges in three major aspects of scientific big data processing as follows: 1) Developing scalable software and algorithms for data- and compute-intensive scientific applications. 2) Proposing new cluster architectures …
Pressure Acquisition System For In Vitro Mitral Valve Analysis, Laura Peck
Pressure Acquisition System For In Vitro Mitral Valve Analysis, Laura Peck
Biomedical Engineering Undergraduate Honors Theses
In vitro testing of the mitral valve chordae tendineae is utilized to aid in the understanding of the stresses that occur in vivo and improve upon surgical solutions that exist for mitral valve repair. This project aimed to design the water control system for a left heart simulation chamber, as well as the pressure acquisition inside the chamber. A solenoid valve was utilized to control the water supply to the tank and was powered utilizing National Instruments software. National Instruments hardware and software was also used with the pressure transducer in order to obtain pressure readings from the chamber. The …
3d Printed Force Transducers For In-Vitro Mitral Valve Chordae Tendineae Force Measurements, Hayley Chandler
3d Printed Force Transducers For In-Vitro Mitral Valve Chordae Tendineae Force Measurements, Hayley Chandler
Biomedical Engineering Undergraduate Honors Theses
Mitral valve surgery is incredibly prevalent in the United States with more than 40,000 mitral valve surgical procedures annually. Improving the imaging techniques used to diagnose these cases requires validation of 3D models through experimental data such as mechanical properties of the tissue. An essential part of this process for the mitral valve is measuring the force experienced by chordae tendineae. This has been achieved with brass force transducers but using a 3D printed design can have many benefits. In this study, 3D printed miniature c-shaped force transducers comparable to previous metal models were designed and created using Solidworks 2016. …
Longitudinal Tracking Of Physiological State With Electromyographic Signals., Robert Warren Stallard
Longitudinal Tracking Of Physiological State With Electromyographic Signals., Robert Warren Stallard
Electronic Theses and Dissertations
Electrophysiological measurements have been used in recent history to classify instantaneous physiological configurations, e.g., hand gestures. This work investigates the feasibility of working with changes in physiological configurations over time (i.e., longitudinally) using a variety of algorithms from the machine learning domain. We demonstrate a high degree of classification accuracy for a binary classification problem derived from electromyography measurements before and after a 35-day bedrest. The problem difficulty is increased with a more dynamic experiment testing for changes in astronaut sensorimotor performance by taking electromyography and force plate measurements before, during, and after a jump from a small platform. A …
Augmented Reality Ultrasound Guidance In Anesthesiology, Golafsoun Ameri
Augmented Reality Ultrasound Guidance In Anesthesiology, Golafsoun Ameri
Electronic Thesis and Dissertation Repository
Real-time ultrasound has become a mainstay in many image-guided interventions and increasingly popular in several percutaneous procedures in anesthesiology. One of the main constraints of ultrasound-guided needle interventions is identifying and distinguishing the needle tip from needle shaft in the image. Augmented reality (AR) environments have been employed to address challenges surrounding surgical tool visualization, navigation, and positioning in many image-guided interventions. The motivation behind this work was to explore the feasibility and utility of such visualization techniques in anesthesiology to address some of the specific limitations of ultrasound-guided needle interventions. This thesis brings together the goals, guidelines, and best …
Power Mobility Sensor Data Collection Verified Through Standardized Pediatric Assessments, Ayshka Elise Rodriguez-Velez
Power Mobility Sensor Data Collection Verified Through Standardized Pediatric Assessments, Ayshka Elise Rodriguez-Velez
UNF Graduate Theses and Dissertations
The collaboration between the School of Engineering and the Department of Physical Therapy at the University of North Florida has introduced the possibility of creating a new environment for pediatric physical therapy assessments. There are currently no methods for remotely monitoring children with impairments. However, with embedded sensor technology in the form of power mobility and accepted therapy assessment tools, remote monitoring can become a possibility. As a part of this work, a ride-on toy car was developed as a remote monitoring device and a case study with a child with a mobility impairment was used as a proof of …
Design And Analysis Of A 3d-Printed, Thermoplastic Elastomer (Tpe) Spring Element For Use In Corrective Hand Orthotics, Kevin Thomas Richardson
Design And Analysis Of A 3d-Printed, Thermoplastic Elastomer (Tpe) Spring Element For Use In Corrective Hand Orthotics, Kevin Thomas Richardson
Theses and Dissertations--Mechanical Engineering
This thesis proposes an algorithm that determine the geometry of 3D-printed, custom-designed spring element bands made of thermoplastic elastomer (TPE) for use in a wearable orthotic device to aid in the physical therapy of a human hand exhibiting spasticity after stroke. Each finger of the hand is modeled as a mechanical system consisting of a triple-rod pendulum with nonlinear stiffness at each joint and forces applied at the attachment point of each flexor muscle. The system is assumed quasi-static, which leads to a torque balance between the flexor tendons in the hand, joint stiffness and the design force applied to …
Wearable Hearing Accessory Technology, Tyler Cindea, Jaime Alcorn, Brooke Draper, Kyle Glascott, Ben Hanna, Robert Thoerner
Wearable Hearing Accessory Technology, Tyler Cindea, Jaime Alcorn, Brooke Draper, Kyle Glascott, Ben Hanna, Robert Thoerner
Williams Honors College, Honors Research Projects
We set out in August 2017 to develop an active noise suppressing device that would be usable both in military and civilian activities. Due to constraints in knowledge and time, we decided our best course of action was to divide the project into two equal projects with the hope to be able to combine them into a single project at the end of the allotted time. This consisted of an active noise suppression device and a passive noise suppression device. The passive device would have no electronic components and the active device would be pure circuitry with no housing. This …