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Full-Text Articles in Biomedical Engineering and Bioengineering
Metabolic Modeling Of Secondary Metabolism In Plant Systems, Lisa M. Leone
Metabolic Modeling Of Secondary Metabolism In Plant Systems, Lisa M. Leone
Masters Theses
In the first part of this research, we constructed a Genome scale Metabolic Model (GEM) of Taxus cuspidata, a medicinal plant used to produce paclitaxel (Taxol®). The construction of the T. cuspidata GEM was predicated on recent acquisition of a transcriptome of T. cuspidata metabolism under methyl jasmonate (MJ) elicited conditions (when paclitaxel is produced) and unelicited conditions (when paclitaxel is not produced). Construction of the draft model, in which transcriptomic data from elicited and unelicited conditions were included, utilized tools including the ModelSEED developed by Argonne National Laboratory. Although a model was successfully created and gapfilled by ModelSEED …
Metabolic Modeling Of Spider Silk Production In E. Coli, Sarah Allred
Metabolic Modeling Of Spider Silk Production In E. Coli, Sarah Allred
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Spider silk has the potential to be a useful biomaterial due to its high tensile strength and elasticity. It is also biocompatible and biodegradable, making it useful for wound dressings and sutures, tissue and bone scaffolds, vessels for drug delivery, and ligament and tendon replacements. In some studies where spider silk has been used to grow cells, the silk has promoted more cell growth than the control. However, it is difficult to obtain the high volume of silk needed for these undertakings on a large scale. Spiders are territorial and cannibalistic, so they cannot be easily farmed. Therefore, spider silk …