Biomedical Engineering and Bioengineering Commons^™

Characterizing The Reproducibility Of The Properties Of Electrospun Poly(D, L-Lactide-Co-Glycolide) Scaffolds For Tissue-Engineered Blood Vessel Mimics, Toni M. Pipes

Master's Theses

“Blood vessel mimics” (BVMs) are tissue-engineered constructs that serve as in vitro preclinical testing models for intravascular devices. The Cal Poly Tissue Engineering lab specifically uses BVMs to test the cellular response to stent implantation. PLGA scaffolds are electrospun in-house using the current “Standard Protocol” and used as the framework for these constructs. The performance of BVMs greatly depends on material and mechanical properties of the scaffolds. It is desirable to create BVMs with reproducible properties so that they can be consistent models that ultimately generate more reliable results for intravascular device testing. Reproducibility stems from the consistency of the …