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Biomedical Engineering and Bioengineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Theses/Dissertations

2014

Open Access Theses

Cartilage injury

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Full-Text Articles in Biomedical Engineering and Bioengineering

Biomechanics And Relaxivity For Functional Imaging Of Articular Cartilage Injury And Degradation, Kateri Elizabeth Fites Apr 2014

Biomechanics And Relaxivity For Functional Imaging Of Articular Cartilage Injury And Degradation, Kateri Elizabeth Fites

Open Access Theses

Osteoarthritis (OA) is a major debilitating health concern and economic burden worldwide, affecting 27 million people in the United States alone. OA often follows tissue injury, and is marked by changes in the structure and biomechanical function of cartilage, including breakdown of extracellular matrix molecules, loss of bulk tissue stiffness, and increase in articular surface friction and wear. Unlike bone and many other tissues, cartilage lacks an intrinsic capacity for regeneration. Advanced OA is typically diagnosed by patient symptoms (e.g. joint pain) and confirmed by radiographic evaluation of joint space narrowing. However, the application of functional imaging to assess ...