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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

2014

Electronic Theses and Dissertations

Micro-channel

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Full-Text Articles in Biomedical Engineering and Bioengineering

Real-Time Bio Sensing Using Micro-Channel Encapsulated Mems Resonators, Ayesha Iqbal Aug 2014

Real-Time Bio Sensing Using Micro-Channel Encapsulated Mems Resonators, Ayesha Iqbal

Electronic Theses and Dissertations

This work presents a label-free bio-molecular detection technique based on realtime monitoring of the resonant frequency of micromechanical thermal-piezoresistive rotational mode disk resonators encapsulated in microfluidic channels. Mass loading via adsorption of molecular layers on the surface of such devices results in a frequency shift. In order to provide a reliable platform for sample-resonator interactions and to protect the resonators from contaminants, the resonators were encapsulated in PDMS-based microfluidic channels. Micro-channel encapsulation also allows insulation of electrical signals from the analyte solution. To characterize the performance of such devices as real-time label-free bio-molecular detectors, the strong non-covalent binding of Avidin ...