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Full-Text Articles in Biomedical Engineering and Bioengineering

Melt Blown Poly(Lactic Acid) For Application As A Tissue Engineering Scaffold, William Horst Gazzola Dec 2012

Melt Blown Poly(Lactic Acid) For Application As A Tissue Engineering Scaffold, William Horst Gazzola

Masters Theses

Poly(lactic acid) (PLA) was melt blown (MB) under varying processing conditions to create webs with micro and nano-architecture. Processing parameters varied were primary air flow rate and collector distance. In total, twenty-one webs were produced and the physical properties of the webs were investigated including, mean fiber diameter and fiber diameter distribution, mean pore diameter and pore size distribution, web thickness, degree of crystallinity, tensile modulus and degradation rate. Four webs, two with micro and two with nano-architecture, thought suitable for use as tissue engineering scaffolds were selected for seeding with A375 human malignant melanoma cells. Cell culture was conducted …


Design Of Experimentation To Systematically Determine The Interaction Between Electrospinning Variables And To Optimize The Fiber Diameter Of Electrospun Poly (D, L-Lactide-Co-Glycolide) Scaffolds For Tissue Engineered Constructs, Yvette S. Castillo Jun 2012

Design Of Experimentation To Systematically Determine The Interaction Between Electrospinning Variables And To Optimize The Fiber Diameter Of Electrospun Poly (D, L-Lactide-Co-Glycolide) Scaffolds For Tissue Engineered Constructs, Yvette S. Castillo

Master's Theses

Cardiac disease causes approximately a third of the deaths in the United States. Furthermore, most of these deaths are due to a condition termed atherosclerosis, which is a buildup of plaque in the coronary arteries, leading to occlusion of normal blood flow to the cardiac muscle. Among the methods to treat the condition, stents are devices that are used to restore normal blood flow in the atherosclerotic arteries. Before advancement can be made to these devices and changes can be tested in live models, a reliable testing method that mimics the environment of the native blood vessel is needed. Dr. …