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Full-Text Articles in Biomedical Engineering and Bioengineering
Implementation Of Physiologic Pressure Conditions In A Blood Vessel Mimic Bioreactor System, Kevin Mark Okarski
Implementation Of Physiologic Pressure Conditions In A Blood Vessel Mimic Bioreactor System, Kevin Mark Okarski
Master's Theses
ABSTRACT
Implementation of Physiologic Pressure Conditions in a Blood Vessel Mimic Bioreactor System
Kevin Mark Okarski
Tissue engineering has traditionally been pursued as a therapeutic science intended for restoring or replacing diseased or damaged biologic tissues or organs. Cal Poly’s Blood Vessel Mimic Laboratory is developing a novel application of tissue engineering as a tool for the preclinical evaluation of intravascular devices. The blood vessel mimic (BVM) system has been previously used to assess the tissue response to deployed stents, but under non-physiologic conditions. Since then, efforts have been made to improve the vessel and bioreactor’s ability to emulate in …
Comparative Studies On Oxygen Mass Transfer For The Design And Development Of A Single-Use Fermentor, Kristan L. Sorenson
Comparative Studies On Oxygen Mass Transfer For The Design And Development Of A Single-Use Fermentor, Kristan L. Sorenson
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Accurate experimental oxygen mass transfer coefficient, a measure of how quickly oxygen travels from a gas bubble to the bulk liquid, is important for comparing performance and for evaluating the oxygen transfer capability of a fermentor. Delays in probe response and changing gas volumes upon start-up of gassing affect the accuracy of oxygen transfer measurements. To mitigate these inaccuracies, a standard correction procedure for oxygen mass transfer data was established for highly oxygenated, well-mixed fermentation systems. Probe response time correction was generated by applying a second-order response model to dissolved oxygen probes and shown to be effective within 4%. By …