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Biomedical Engineering and Bioengineering Commons™
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- 4-D CT (1)
- Biomimetic mineralization (1)
- Bone tissue engineering (1)
- Brachytherapy (1)
- Brain Computer Interface (1)
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- Brain Controlled Switch (1)
- Cartilage constructs (1)
- Composite scaffold (1)
- Computational Modeling (1)
- Deformation model (1)
- Dystonia (1)
- Electroencephalography (EEG) (1)
- Electrophysiology (1)
- Electrospinning (1)
- Flat Panel Detector (1)
- Flatfoot (1)
- Foot and Ankle (1)
- Gymnasts (1)
- HDR (1)
- Heart valve (1)
- Joint mechanics (1)
- Ligament Strain (1)
- Ligaments (1)
- MSCs (1)
- Mechanical stimulatoin (1)
- Medical Simulator (1)
- Nanocrystalline hydroxyapatite (1)
- Nerve Conduction Study Simulator (1)
- Piezoelectric sensor (1)
- Pulse wave monitoring (1)
Articles 1 - 14 of 14
Full-Text Articles in Biomedical Engineering and Bioengineering
Development Of A Rigid Body Computational Model For Investigation Of Wrist Biomechanics, Benjamin Majors
Development Of A Rigid Body Computational Model For Investigation Of Wrist Biomechanics, Benjamin Majors
Theses and Dissertations
The wrist is one of the most complex joints in the human body. As such, the wrist joint is difficult to model due to the number of bones involved and its intricate soft tissue interactions. Many studies have attempted modeling the wrist previously; however, the majority of these studies simplify the joint into two-dimensions or idealized mechanical joints to reduce the complexity of the simulation. While these approaches still yield valuable information, the omission of a third-dimension or geometry defined movements limits the models’ usefulness in predicting joint function under non-idealized conditions. Therefore, the goal of this study was to …
4-D Modeling Of Displacement Vector Fields For Improved Radiation Therapy, Elizabeth Zachariah
4-D Modeling Of Displacement Vector Fields For Improved Radiation Therapy, Elizabeth Zachariah
Theses and Dissertations
In radiation therapy, it is imperative to deliver high doses of radiation to the tumor while reducing radiation to the healthy tissue. Respiratory motion is the most significant source of errors during treatment. Therefore, it is essential to accurately model respiratory motion for precise and effective radiation delivery. Many approaches exist to account for respiratory motion, such as controlled breath hold and respiratory gating, and they have been relatively successful. They still present many drawbacks. Thus, research has been expanded to tumor tracking. This paper presents a spatio-temporal model for four dimensional CT reconstruction. The method begins with a set …
Synthesis And Characterization Of Electrospun Gelatin/Dendrimer Scaffold Encapsulated With A Silver As A Potential Antimicrobial Wound Dressing, Alpana Dongargaonkar
Synthesis And Characterization Of Electrospun Gelatin/Dendrimer Scaffold Encapsulated With A Silver As A Potential Antimicrobial Wound Dressing, Alpana Dongargaonkar
Theses and Dissertations
A novel nanofiber scaffold was fabricated and characterized as a potential antimicrobial wound dressing. Half generation polyamidoamine (PAMAM) dendrimer G3.5 was covalently conjugated to gelatin. Gelatin alone or with gelatin-dendrimer conjugates was electrospun into nanofiber scaffolds. Gelatin is a derivative of natural collagen, and it is biocompatible, non-toxic and inexpensive, making it a desirable component in a wound dressing. Dendrimers are synthetic polymers comprising of a central core, internal branches and reactive surface groups. They provide a structurally controlled architecture for drug release. Silver was incorporated into the scaffold in situ due to its broad spectrum of antimicrobial properties. The …
Development Of Electroencephalography Based Brain Controlled Switch And Nerve Conduction Study Simulator Software, Kai Qian
Theses and Dissertations
This thesis investigated the development of an EEG-based brain controlled switch and the design of a software for nerve conduction study. For EEG-based brain controlled switch, we proposed a novel paradigm for an online brain-controlled switch based on Event-Related Synchronizations (ERDs) following external sync signals. Furthermore, the ERD feature was enhanced by 3 event-related moving averages and the performance was tested online. Subjects were instructed to perform an intended motor task following an external sync signal in order to turn on a virtual switch. Meanwhile, the beta-band (16-20Hz) relative ERD power (ERD in reverse value order) of a single EEG …
In Vitro Evaluation Of Mechanical Heart Valve Performance Using A Novel Test Chamber In An Automated Mock Circulatory Loop, Antonio Walker
In Vitro Evaluation Of Mechanical Heart Valve Performance Using A Novel Test Chamber In An Automated Mock Circulatory Loop, Antonio Walker
Theses and Dissertations
Valvular heart disease (VHD) continues to have significant effects on many people’s lives, with numbers expected to grow tremendously over the next few years. Individuals suffering from severe valvular heart disease usually require a heart valve transplant in order to restore the native valve’s vital unidirectional flow regulation. Therefore, artificial heart valve (AHV) research is of very high importance. Previous research studies have provided substantial input in the realm of AHV design relative to durability, thrombotic and hemolytic potential, and overall functionality. However, modifications continue to be warranted due to limitations in the accuracy and time efficiency of the in …
Arterial Waveform Measurement Using A Piezoelectric Sensor, Ruizhi Zhang
Arterial Waveform Measurement Using A Piezoelectric Sensor, Ruizhi Zhang
Theses and Dissertations
This study aims to develop a new method to monitor peripheral arterial pulse using a PVDF piezoelectric sensor. After comparing different locations of sensor placement, a specific sensor wrap for the finger was developed. Its composition, size, and location make it inexpensive and very convenient to use. In order to monitor the effectiveness of the sensor at producing a reliable pulse waveform, a monitoring system, including the PZT sensor, ECG, pulse-oximeter, respiratory sensor, and accelerometer was setup. Signal analysis from the system helped discover that the PZT waveform is relative to the 1st derivative of the artery pressure wave. Also, …
Real Time 3-D Tracking Of The High Dose Rate Radiation Source Using A Flat Panel Detector, Aditya Bondal
Real Time 3-D Tracking Of The High Dose Rate Radiation Source Using A Flat Panel Detector, Aditya Bondal
Theses and Dissertations
A number of QA procedures have been developed for Breast Brachytherapy treatments, yet none guarantee accurate dose delivery or allow conformation of the actual source position leading to errors sometimes going unnoticed. The objective of this study is to track the exact path the HDR source would follow in real time. The exit radiation of the HDR source was used to image a well defined matrix of markers. The images were acquired using FPD and were processed to obtain projection coordinates while an x-ray calibration image was processed to obtain marker coordinates. Each marker along with its projection represents a …
Eye Movements In Elite Athletes - An Index For Performance., Harshad Hegde
Eye Movements In Elite Athletes - An Index For Performance., Harshad Hegde
Theses and Dissertations
Introduction: In gymnastics, athletes perform twisting and flipping skills at high angular velocities. These athletes rely heavily on sensory information from the visual, proprioceptive, and vestibular systems. The vestibulo-ocular reflex (VOR) is responsible for stabilizing the visual field on the retina during head movement. To accomplish this, the eyes are reflexively moved in a direction opposite the head. In a twisting gymnast, this actually reduces the ability of gymnasts to see the landing during airborne skills. Hence it becomes necessary for the gymnasts to cancel or suppress their VOR in order to view the landing. Objective: The purpose of this …
Effect Of Mechanical Stimulation On Mesenchymal Stem Cell Seeded Cartilage Constructs, Karin Wartella
Effect Of Mechanical Stimulation On Mesenchymal Stem Cell Seeded Cartilage Constructs, Karin Wartella
Theses and Dissertations
Cartilage tissue engineered constructs using mesenchymal stem cells were stimulated with 3 different stimulation algorithms to achieve characteristics mimicking the superficial tangential zone of articular cartilage. The stimulation algorithm of both compression and tension without an offset had the best properties out of all the evaluated groups.
Synthesis And Characterization Of A Novel Amphiphilic Core-Corona Hyperbranched Polymer, Composed Of Ehmo And Ehmopeg, For Drug Delivery., Khushboo Sharma
Synthesis And Characterization Of A Novel Amphiphilic Core-Corona Hyperbranched Polymer, Composed Of Ehmo And Ehmopeg, For Drug Delivery., Khushboo Sharma
Theses and Dissertations
A novel amphiphilic core-corona hyperbranched polymer, composed of 3-ethyl-3-(hydroxylmethyl) oxetane (EHMO) and PEGylated EHMO (EHMOPEG), was synthesized through cationic ring opening polymerization. Nuclear Magnetic Resonance spectroscopy (NMR), Dynamic Light Scattering (DLS), and Fourier Transform Infrared spectroscopy (FTIR) were used to characterize the polymer structure and degree of branching. It was found that the degree of branching (DOB) of the polymer was affected by the weight % ratios of EHMO/EHMOPEG used in polymerization. As the weight % ratio of EHMO/ EHMOPEG decreased, the DOB was observed to increase. Polymeric particles based on the synthesized polymer were prepared using the O/W (Oil …
A Comparative Analysis Of Methods For Baseline Drift Removal In Preterm Infant Respiration Signals, Pallavi Ramnarain
A Comparative Analysis Of Methods For Baseline Drift Removal In Preterm Infant Respiration Signals, Pallavi Ramnarain
Theses and Dissertations
Breathing is a vital function intrinsic to the survival of any human being. In preterm infants it is an important indicator of maturation and feeding competency, which is a hallmark for hospital release. The recommended method of measurement of infant respiration is the use of thermistors. Accurate event detection within thermistor generated signals relies heavily upon effective noise reduction, specifically baseline drift removal. Baseline drift originates from several sensor-based factors, including thermistor placement within the sensor and in relation to the infant nares. This work compares four methods for baseline drift removal using the same event detection algorithm. The methods …
The Design And Validation Of A Novel Computational Simulation Of The Leg For The Investigation Of Injury, Disease, And Surgical Treatment, Joseph Iaquinto
The Design And Validation Of A Novel Computational Simulation Of The Leg For The Investigation Of Injury, Disease, And Surgical Treatment, Joseph Iaquinto
Theses and Dissertations
Computational modeling of joints and their function, a developing field, is becoming a significant health and wellness tool of our modern age. Due to familiarity of prior research focused on the lower extremity, a foot and ankle 3D computational model was created to explore the potential for these computational methods. The method of isolating CT scanned tissue and rendering a patient specific anatomy in the digital domain was accomplished by the use of MIMICS™ , SolidWorks™, and COSMOSMotion™ – all available in the commercial domain. The kinematics of the joints are driven solely by anatomically modeled soft tissue applied to …
Mineralization Potential Of Electrospun Pdo-Nha-Fibrinogen Scaffolds Intended For Cleft Palate Repair, Isaac Rodriguez
Mineralization Potential Of Electrospun Pdo-Nha-Fibrinogen Scaffolds Intended For Cleft Palate Repair, Isaac Rodriguez
Theses and Dissertations
The overall goal of this study was to identify mineralized scaffolds which can serve as potential alternatives to bone graft substitutes intended for cleft palate repair. The aim of this preliminary study was to evaluate the role of fibrinogen (Fg) and nano-hydroxyapatite (nHA) in enhancing mineralization potential of polydioxanone (PDO) electrospun scaffolds. Scaffolds were fabricated by blending PDO:nHA:Fg in the following weight ratios: 100:0:0, 50:25:25, 50:50:0, 50:0:50, 0:0:100 and 0:50:50. Scaffolds were immersed in different simulated body fluids for 5 and 14 days to induce mineralization. The inclusion of fibrinogen induced sheet-like mineralization while individual fiber mineralization was noticed in …
Electrophysiological Analysis In An Animal Model Of Dystonia, Kunal Chaniary
Electrophysiological Analysis In An Animal Model Of Dystonia, Kunal Chaniary
Theses and Dissertations
Dystonia is a movement disorder characterized by patterned, repetitive, and sustained muscle contractions that cause ineffective and often painful movements. The overall goal of this project was to understand the physiological mechanisms of dystonia in a rodent model as a basis for developing innovative treatments for secondary dystonias. The first half of the project was focused at developing essential techniques for systematically investigating the movement disorder in these animals. For achieving this, an innovative, multi-faceted approach was pursued starting with electromyographic (EMG) analysis for animal model validation, gait analysis for dystonia quantification, and development of a novel stereotaxic apparatus for …