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Computer Simulation Of Intracranial Hemodynamics During The Induction Phase Of Anesthesia, Gopinath P. Sundaram

Theses

The induction of general anesthesia is associated with severe hemodynamic compromises which, in turn, may cause acute elevation of intracranial pressure (ICP). Quantitative assessment of cerebrovascular responses arising from multiple mechanical and pharmacological interventions occurring in a short time interval require a large number of human studies which are difficult to perform. The purpose of this project is to evaluate the effect of various stimuli on the intracranial hemodynamics during induction using a mathematical model of cerebrovascular circulation.

A five compartmental model of the cerebrovascular system is used for our simulation. Autoregulation is modeled by adjusting arterial-arteriolar resistance in order …