Open Access. Powered by Scholars. Published by Universities.®

Biomedical Engineering and Bioengineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 2 of 2

Full-Text Articles in Biomedical Engineering and Bioengineering

Engineering The Phospholipid Monolayer On Fluorocarbon, Hydrocarbon, And Liquid Crystal Nanodroplets For Applications In Biosensing, Rajarshi Chattaraj Jan 2018

Engineering The Phospholipid Monolayer On Fluorocarbon, Hydrocarbon, And Liquid Crystal Nanodroplets For Applications In Biosensing, Rajarshi Chattaraj

Mechanical Engineering Graduate Theses & Dissertations

Nanodroplets (NDs) are liquid-in-liquid dispersions of ~100-800 nm size range that are often stabilized by a shell of lipids, polymer, proteins, or surfactants. NDs have been explored for a variety of biomedical applications, mostly involving drug formulation and delivery. However, the unique properties of encapsulated liquids, and the effects of interfacial chemistry on these properties, makes NDs potentially powerful candidates for new biosensing technologies. This dissertation explores different oil-in-water or fluorocarbon-in-water ND systems for in-solution sensing of biomarkers as both a platform for diagnostic assays and as a precursor to in vivo biosensing. Nanodroplets, because of their size, provide a ...


Design And Development Of Multilayer Vascular Graft, Krishna Madhavan Jan 2011

Design And Development Of Multilayer Vascular Graft, Krishna Madhavan

Mechanical Engineering Graduate Theses & Dissertations

Vascular graft is a widely-used medical device for the treatment of vascular diseases such as atherosclerosis and aneurysm as well as for the use of vascular access and pediatric shunt, which are major causes of mortality and morbidity in this world. Dysfunction of vascular grafts often occurs, particularly for grafts with diameter less than 6mm, and is associated with the design of graft materials. Mechanical strength, compliance, permeability, endothelialization and availability are issues of most concern for vascular graft materials. To address these issues, we have designed a biodegradable, compliant graft made of hybrid multilayer by combining an intimal equivalent ...