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Capillary Perfusion Kinematics In Lungs Of Oxygen-Tolerant Rats, Madhavi Ramakrishna
Capillary Perfusion Kinematics In Lungs Of Oxygen-Tolerant Rats, Madhavi Ramakrishna
Master's Theses (2009 -)
Motivation:
Prolonged exposure to oxygen at high concentrations (hyperoxia), a common treatment for hypoxemia, is toxic to the lungs. Rats exposed to 85% O2 for 5-7 days develop tolerance to the otherwise lethal effects of 100% O2. Elucidating the factors that contribute to this tolerance could further our understanding of the mechanisms of lung O2 toxicity. Since vascular remodeling involving loss of capillary volume and endothelial surface area has been reported in lungs from rats exposed to 85% O2 for 7 days, we were interested in evaluating the effect of this hyperoxia model on lung …