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Pulmonary Particle Deposition In Relation To Age, Body Weight, And Species, Lisa M. Weber
Pulmonary Particle Deposition In Relation To Age, Body Weight, And Species, Lisa M. Weber
Electronic Theses and Dissertations
As a result of dissimilarity in lung morphometry and physiological conditions, therapeutic aerosol particles deposit differently in humans of various ages and body weights. These particles also deposit differently in non-human species that are often utilized in inhalation and dosing studies. The focus of this work is to determine the optimal particle size and deposition (traditional efficiency and volume-weighted) of therapeutic particles in humans of both genders ranging in age from 3 months old to 21 years old and three non-human species (B6C3F1 mouse, Long-Evans hooded rat, and Beagle dog). This study finds that in humans, both optimal …