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Full-Text Articles in Biomedical Engineering and Bioengineering
Femtosecond Laser Patterned Templates And Imprinted Polymer Structures, Deepak Rajput
Femtosecond Laser Patterned Templates And Imprinted Polymer Structures, Deepak Rajput
Doctoral Dissertations
Femtosecond laser machining is a direct-write lithography technique by which user-defined patterns are efficiently and rapidly generated at the surface or within the bulk of transparent materials. When femtosecond laser machining is performed with tightly focused amplified pulses in single-pulse mode, transparent substrates like fused silica can be surface patterned with high aspect ratio (>10:1) and deep (>10 μm) nanoholes. The main objective behind this dissertation is to develop single-pulse amplified femtosecond laser machining into a novel technique for the production of fused silica templates with user-defined patterns made of high aspect ratio nanoholes. The size of the …
Modulation Of Bone And Nerve Cell Behavior Using Biodegradable Polymer Networks, Lei Cai
Modulation Of Bone And Nerve Cell Behavior Using Biodegradable Polymer Networks, Lei Cai
Doctoral Dissertations
This dissertation presents novel biodegradable and photo-crosslinkable building blocks to achieve polymer networks with controlled surface chemistry, stiffness, and topographical features for investigating cell-material interactions and targeting hard and soft tissue engineering applications. Chapter I reviews the recent progress in polymeric gel systems and how their physical properties can be tailored to regulate cell functions and satisfy the clinical needs. Chapter II presents a facile method to synthesize photo-crosslinkable poly(epsilon-caprolactone) acrylates (PCLAs) and reveal tunable cell responses to photo-crosslinked PCLAs. Chapter III investigates the mechanism of colorization in preparing crosslinkable polymers by reacting hydroxyl-containing polymers with unsaturated anhydrides or acyl …