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Full-Text Articles in Biomedical Engineering and Bioengineering
Simulation Of A Continuum Tumor Model Using Distributed Computing., Dylan A Goodin
Simulation Of A Continuum Tumor Model Using Distributed Computing., Dylan A Goodin
Electronic Theses and Dissertations
Mathematical modeling aims to provide a theoretical framework for understanding tissue dynamics and for establishing treatment response for diseased tissues, such as tumors. Previously published continuum models have successfully represented idealized two-dimensional and three-dimensional tissue for short periods of time. A recently published continuum model of cancer increases model complexity and describes three-dimensional tissue that, due to the required complexity of the geometric multigrid solver, can only be feasibly applied to millimeter-scale simulations. Furthermore, the computational cost for such models has hindered their application in the laboratory and in the clinic. With computational demands greatly outpacing current openMP-based approaches on …
Feasibility Study Of Intelligent Lvad Control For Optimal Heart Failure Therapy., John A. Karlen Iii
Feasibility Study Of Intelligent Lvad Control For Optimal Heart Failure Therapy., John A. Karlen Iii
Electronic Theses and Dissertations
Background: Left ventricular assist devices (LVAD) are operated at constant speeds (rpm), consequently, pump flow is passively determined by the pressure difference between the LV and aorta. Since the diastolic pressure gradient (~70 mmHg) is much larger than the systolic gradient (~10 mmHg), the majority of pump flow occurs during systole. This limitation results in sub-optimal LV volume unloading, LV washing, and diminished vascular pulsatility that may be associated with increased risk for clinically-significant adverse events, including stroke, bleeding, arteriovenous malformations, and aortic insufficiency. To address these clinical adverse events, an intelligent control strategy using pump speed modulation was developed …
Suture-Less Trocar Site Closure Clip, Hares A. Patel
Suture-Less Trocar Site Closure Clip, Hares A. Patel
Electronic Theses and Dissertations
Introduction: Following laparoscopic surgery, there is a need, in many cases, to close trocar sites to prevent hernias. Currently, devices that exist on the market are suture based, but the lack of standardization in the suturing techniques together with the time-consuming nature of the procedure leads to the need for improvement in trocar site closure products. Trocar closure sites do not need to be fully closed on the fascial layer; rather, sufficiently blocking the hole at the abdominal wall can significantly reduce post-operative herniation. A retrospective study on trocar site herniation (TSH) after laparoscopic surgery indicates a TSH incidence …
A Deep Learning Approach To Detect Diabetic Retinopathy In Fundus Images., Winston R. Furtado
A Deep Learning Approach To Detect Diabetic Retinopathy In Fundus Images., Winston R. Furtado
Electronic Theses and Dissertations
Background: Diabetic retinopathy is a disease caused due by complications of diabetes mellitus which can lead to blindness. About 33% of the US population with diabetes also show symptoms for diabetes retinopathy. If not treated, diabetic retinopathy worsens over time by progressing through two main pathological stages of non-proliferative and proliferative and four clinical stages. While the diagnostic accuracy of detecting diabetic retinopathy through machine learning have shown to be successful for OCT images, the accuracy of ultra-widefield fundus images have yet to be fully reported. This paper describes a method to non-invasively detect and diagnose diabetic retinopathy from ultra-widefield …