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Full-Text Articles in Biomedical Engineering and Bioengineering
Design Of Three-Dimensional Axon Stretch Growth Device, Fayekah Assanah
Design Of Three-Dimensional Axon Stretch Growth Device, Fayekah Assanah
Theses
Spinal Cord Injury (SCI) causes destruction and degeneration of axons in the white matter of the spinal cord, resulting in functional loss and paralysis. A successful treatment of SCI requires axons to regenerate across damaged regions. Current studies focus on identifying mechanisms to promote axon regeneration in lesions and have yet to be successful in preventing nerve degeneration due to scar tissue formation. Establishing axonal bridges over long distances of SCI lesions remains a challenge, resulting in poor functional recovery. Instead of relying on promoting axon regeneration into lesions, Pfister et al. has developed a transplantable nervous tissue construct spanned …
The Extraction Of Type 1 Collagen And The Fabrication Of Multi-Filament Embedded Hydrogels For Guided Nerve Regeneration, Mevan Lakmal Siriwardane
The Extraction Of Type 1 Collagen And The Fabrication Of Multi-Filament Embedded Hydrogels For Guided Nerve Regeneration, Mevan Lakmal Siriwardane
Theses
Each year, there are approximately 11,000 new cases of spinal cord injury (SCI) in the United States [2]. There have been some success in pre-clinical studies to induce axonal generation, but the reconnection of axons over large distances remains the greatest challenge. Since the development of nerve conduit to facilitate general axonal regeneration, the primary focus has changed to directing the regeneration of axons while also promoting their outgrowth over very extensive lesions to ensure functional recovery of transected nerves during in vitro experiments by using natural materials such as type I collagen, which is the largest constituent of the …