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Full-Text Articles in Biomedical Engineering and Bioengineering
Temporal And Spatial Effects Of Shock Overpressure On Blood-Brain Barrier Permeability In Blast-Induced Traumatic Brain Injury, Matthew Joseph Kuriakose
Temporal And Spatial Effects Of Shock Overpressure On Blood-Brain Barrier Permeability In Blast-Induced Traumatic Brain Injury, Matthew Joseph Kuriakose
Dissertations
Exposure to shock waves is the leading cause of traumatic brain injury (TBI) in military personnel and blast-induced TBI (bTBI) is considered the signature wound in recent conflicts in Iraq and Afghanistan. Many researchers attempt to replicate field-relevant shock waves in laboratory settings through the use of gas-driven shock tubes in order to investigate the generation and propagation of shock waves and also explore possible mechanisms of bTBI. Among several injury mechanisms of bTBI, damage to the blood-brain barrier (BBB) has been identified as a potential candidate and has been the focus of several clinical and experimental investigations aimed to …
Changes In Nadph Oxidase (Nox) Protein Isoforms And Downstream Reactions As Function Of Time And Overpressure In Blast Tbi, Smit Prakash Shah
Changes In Nadph Oxidase (Nox) Protein Isoforms And Downstream Reactions As Function Of Time And Overpressure In Blast Tbi, Smit Prakash Shah
Theses
Blast-induced Traumatic brain injury (bTBI) is a leading cause of morbidity in soldiers on the battlefield and training sites with long-term neurological and psychological pathologies. Among many pathological sequela of blast TBI, oxidative stress has been identified as a major factor contributing to the pathophysiology of bTBI. Recent studies have demonstrated activation of oxidative stress pathways following blast injury but their distribution among different brain regions as function of post injury time and Blast over pressure (BOP) have not been explored. The present study examines the protein expression of NADP oxidase (NOX) isoforms 1 & 2, corresponding superoxide production, a …