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Biomedical Engineering and Bioengineering Commons™
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City University of New York (CUNY)
Shear stress; cyclic strain; glycoclayx; heparan sulfate proteoglycan; syndecan 4; integrins; mechanotransduction; embryonic stem cell; endothelial cell
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Mechanotransduction Modulates The Effect Of Mechanical Forces (Fluid Shear Stress And Cyclic Strain) On Embryonic Stem Cell Differentiation Toward Vascular Endothelial Cells, Maria Nikmanesh
Dissertations, Theses, and Capstone Projects
The isolation of human ES cells (hES) in 1998 remarkably elevated the interest in the cell therapy capability of ES cells and moved this concept one step closer to reality. Embryonic stem cells with their potential for both self-renewal and directed differentiation have received increasing attention in applications in tissue engineering and repair, cell therapy, and regenerative medicine.
The differentiation of embryonic stem cells into desired lineages depends on the chemical environment of the “niche”, and for certain lineages such as the vascular lineage that must function in a mechanical environment, the timely imposition of mechanical forces is critical. In …