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Elastin Like Polypeptides As Drug Delivery Vehicles In Regenerative Medicine Applications, Alex Leonard
Elastin Like Polypeptides As Drug Delivery Vehicles In Regenerative Medicine Applications, Alex Leonard
USF Tampa Graduate Theses and Dissertations
Elastin like polypeptides (ELPs) are a class of naturally derived biomaterials that are non-immunogenic, genetically encodable, and biocompatible making them ideal for a variety of biomedical applications, ranging from drug delivery to tissue engineering. Also, ELPs undergo temperature-mediated inverse phase transitioning, which allows them to be purified in a relatively simple manner from bacterial expression hosts. Being able to genetically encode ELPs allows for the incorporation of bioactive peptides and functionalization of ELPs. This work utilizes ELPs for regenerative medicine and drug delivery.
The goal of the first study was to synthesize a biologically active epidermal growth factor-ELP (EGF-ELP) fusion …