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Theses/Dissertations

Life Sciences

University of Colorado, Boulder

Chemical & Biological Engineering Graduate Theses & Dissertations

Fibronectin

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Connecting Protein Structure And Dynamics On Biomaterials With The Foreign Body Response, David Faulon Marruecos Jan 2018

Connecting Protein Structure And Dynamics On Biomaterials With The Foreign Body Response, David Faulon Marruecos

Chemical & Biological Engineering Graduate Theses & Dissertations

The harsh environment of the foreign body response (FBR) has the potential to negatively impact the implantations of biomaterials in the body. The FBR is initiated by inflammatory cells that recognize the material as foreign through surface-adsorbed proteins. When proteins interact with surfaces, they can unfold and expose epitopes that may be recognized by immune cells and trigger a series of reactions. Importantly, the presentation of unfolded proteins is directly influenced by the highly dynamic and heterogeneous behavior of proteins in near-surface environments, as well as by the physicochemical features of the underlying surface. Such behavior is the result of ...