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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 4 of 4
Full-Text Articles in Biomedical Engineering and Bioengineering
Integration Of Neural Architecture Within A Finite Element Framework For Improved Neuromusculoskeletal Modeling, Victoria L. Volk, Landon D. Hamilton, Donald R. Hume, Kevin B. Shelburne, Clare K. Fitzpatrick
Integration Of Neural Architecture Within A Finite Element Framework For Improved Neuromusculoskeletal Modeling, Victoria L. Volk, Landon D. Hamilton, Donald R. Hume, Kevin B. Shelburne, Clare K. Fitzpatrick
Mechanical and Biomedical Engineering Faculty Publications and Presentations
Neuromusculoskeletal (NMS) models can aid in studying the impacts of the nervous and musculoskeletal systems on one another. These computational models facilitate studies investigating mechanisms and treatment of musculoskeletal and neurodegenerative conditions. In this study, we present a predictive NMS model that uses an embedded neural architecture within a finite element (FE) framework to simulate muscle activation. A previously developed neuromuscular model of a motor neuron was embedded into a simple FE musculoskeletal model. Input stimulation profiles from literature were simulated in the FE NMS model to verify effective integration of the software platforms. Motor unit recruitment and rate coding …
Novel Insights Into Negative Pressure Wound Healing From An In Situ Porcine Perspective, Jacob G. Hodge, Ashley L. Pistorio, Christopher A. Neal, Hongyan Dai, Jennifer G. Nelson-Brantley, Molly E. Steed, Richard A. Korentager, David S. Zamierowski, Adam J. Mellott
Novel Insights Into Negative Pressure Wound Healing From An In Situ Porcine Perspective, Jacob G. Hodge, Ashley L. Pistorio, Christopher A. Neal, Hongyan Dai, Jennifer G. Nelson-Brantley, Molly E. Steed, Richard A. Korentager, David S. Zamierowski, Adam J. Mellott
School of Medicine Faculty Publications
Negative pressure wound therapy (NPWT) is used clinically to promote tissue formation and wound closure. In this study, a porcine wound model was used to further investigate the mechanisms as to how NPWT modulates wound healing via utilization of a form of NPWT called the vacuum-assisted closure. To observe the effect of NPWT more accurately, non-NPWT control wounds containing GranuFoam™ dressings, without vacuum exposure, were utilized. In situ histological analysis revealed that NPWT enhanced plasma protein adsorption throughout the GranuFoam™, resulting in increased cellular colonization and tissue ingrowth. Gram staining revealed that NPWT decreased bacterial dissemination to adjacent tissue with …
Somatic Inhibition By Microscopic Magnetic Stimulation, Hui Ye
Somatic Inhibition By Microscopic Magnetic Stimulation, Hui Ye
Biology: Faculty Publications and Other Works
Electric currents can produce quick, reversible control of neural activity. Externally applied electric currents have been used in inhibiting certain ganglion cells in clinical practices. Via electromagnetic induction, a miniature-sized magnetic coil could provide focal stimulation to the ganglion neurons. Here we report that high-frequency stimulation with the miniature coil could reversibly block ganglion cell activity in marine mollusk Aplysia californica, regardless the firing frequency of the neurons, or concentration of potassium ions around the ganglion neurons. Presence of the ganglion sheath has minimal impact on the inhibitory effects of the coil. The inhibitory effect was local to the …
The Hate Within, Kora Kukk
The Hate Within, Kora Kukk
Honors College
A novel in its beginning stages, The Hate Within (May 2021) is the product of discovering a way to be able to eloquently combine biomedical engineering with creative writing which will intrigue young adult readers. This thesis contains the first few chapters of the story along with an additional journal entry, the story’s outline with a list of plot events, and a disquisition exploring the motivation and methodology behind creating this thesis.The novel is about a junior in high school named Alaita. She is a super sweet, kind, and popular girl in school until one day she is diagnosed with …