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Full-Text Articles in Biomedical Engineering and Bioengineering

Gait Rehabilitation Using Functional Electrical Stimulation Induces Changes In Ankle Muscle Coordination In Stroke Survivors: A Preliminary Study, Jessica L. Allen, Lena H. Ting, Trisha M. Kesar Dec 2018

Gait Rehabilitation Using Functional Electrical Stimulation Induces Changes In Ankle Muscle Coordination In Stroke Survivors: A Preliminary Study, Jessica L. Allen, Lena H. Ting, Trisha M. Kesar

Faculty & Staff Scholarship

No abstract provided.


Analytical Cpg Model Driven By Limb Velocity Input Generates Accurate Temporal Locomotor Dynamics, Sergiy Yakovenko, Anton Sobinov, Valeriya Gritsenko Jan 2018

Analytical Cpg Model Driven By Limb Velocity Input Generates Accurate Temporal Locomotor Dynamics, Sergiy Yakovenko, Anton Sobinov, Valeriya Gritsenko

Faculty & Staff Scholarship

The ability of vertebrates to generate rhythm within their spinal neural networks is essential for walking, running, and other rhythmic behaviors. The central pattern generator (CPG) network responsible for these behaviors is well-characterized with experimental and theoretical studies, and it can be formulated as a nonlinear dynam- ical system. The underlying mechanism responsible for locomotor behavior can be expressed as the process of leaky integration with resetting states generating appropriate phases for changing body velocity. The low-dimensional input to the CPG model generates the bilateral pattern of swing and stance modulation for each limb and is consistent with the desired …


Development Of A Dynamic Model And Control System For Load-Following Studies Of Supercritical Pulverized Coal Power Plants, Parikshit Sarda, Elijah Hedrick, Katherine Reynolds, Debangsu Bhattacharyya, National Energy Technology Laboratory Jan 2018

Development Of A Dynamic Model And Control System For Load-Following Studies Of Supercritical Pulverized Coal Power Plants, Parikshit Sarda, Elijah Hedrick, Katherine Reynolds, Debangsu Bhattacharyya, National Energy Technology Laboratory

Faculty & Staff Scholarship

Traditional energy production plants are increasingly forced to cycle their load and operate under low-load conditions in response to growth in intermittent renewable generation. A plant-wide dynamic model of a supercritical pulverized coal (SCPC) power plant has been developed in the Aspen Plus Dynamics® (APD) software environment and the impact of advanced control strategies on the transient responses of the key variables to load-following operation and disturbances can be studied. Models of various key unit operations, such as the steam turbine, are developed in Aspen Custom Modeler® (ACM) and integrated in the APD environment. A coordinated control system (CCS) is …


Effects Of Water Content And Particle Size On Yield And Reactivity Of Lignite Chars Derived From Pyrolysis And Gasification, Yong Huang, Yonggang Wang, Hao Zhou, Yaxuan Gao, Deliang Xu, Lei Bai, Shu Zhang Jan 2018

Effects Of Water Content And Particle Size On Yield And Reactivity Of Lignite Chars Derived From Pyrolysis And Gasification, Yong Huang, Yonggang Wang, Hao Zhou, Yaxuan Gao, Deliang Xu, Lei Bai, Shu Zhang

Faculty & Staff Scholarship

Water inside coal particles could potentially enhance the interior char–steam reactions during pyrolysis and gasification. This study aims to examine the effects of water contents on the char conversion during the pyrolysis and gasification of Shengli lignite. The ex-situ reactivities of chars were further analyzed by a thermo gravimetric analyzer (TGA). Under the pyrolysis condition, the increase in water contents has monotonically decreased the char yields only when the coal particles were small (μm). In contrast, the water in only large coal particles (0.9–2.0 mm) has clearly favored the increase in char conversion during the gasification condition where 50% steam …


Enhanced Hot Electron Lifetimes In Quantum Wells With Inhibited Phonon Coupling, Hamidreza Esmaielpour, Vincent R. Whiteside, Herath P. Piyathilaka, Sangeetha Vijeyaragunathan, Bin Wang, Echo Adcock-Smith, Kenneth P. Roberts, Tetsuya D. Mishima, Michael B. Santos, Alan D. Bristow, Ian R. Sellers Jan 2018

Enhanced Hot Electron Lifetimes In Quantum Wells With Inhibited Phonon Coupling, Hamidreza Esmaielpour, Vincent R. Whiteside, Herath P. Piyathilaka, Sangeetha Vijeyaragunathan, Bin Wang, Echo Adcock-Smith, Kenneth P. Roberts, Tetsuya D. Mishima, Michael B. Santos, Alan D. Bristow, Ian R. Sellers

Faculty & Staff Scholarship

Hot electrons established by the absorption of high-energy photons typically thermalize on a picosecond time scale in a semiconductor, dissipating energy via various phonon-mediated relaxation pathways. Here it is shown that a strong hot carrier distribution can be produced using a type-II quantum well structure. In such systems it is shown that the dominant hot carrier thermalization process is limited by the radiative recombination lifetime of electrons with reduced wavefunction overlap with holes. It is proposed that the subsequent reabsorption of acoustic and optical phonons is facilitated by a mismatch in phonon dispersions at the InAs-AlAsSb interface and serves to …


Quantum Confined Peptide Assemblies With Tunable Visible To Near-Infrared Spectral Range, Kai Tao, Zhen Fan, Leming Sun, Pandeeswar Makam, Zhen Tian, Mark Ruegsegger, Shira Shaham-Niv, Derek Hansford, Ruth Aizen, Zui Pan, Scott Galster, Jianjie Ma, Fan Yuan, Mingsu Si, Songnan Qu, Mingjun Zhang, Ehud Gazit, Junbai Li Jan 2018

Quantum Confined Peptide Assemblies With Tunable Visible To Near-Infrared Spectral Range, Kai Tao, Zhen Fan, Leming Sun, Pandeeswar Makam, Zhen Tian, Mark Ruegsegger, Shira Shaham-Niv, Derek Hansford, Ruth Aizen, Zui Pan, Scott Galster, Jianjie Ma, Fan Yuan, Mingsu Si, Songnan Qu, Mingjun Zhang, Ehud Gazit, Junbai Li

Faculty & Staff Scholarship

Quantum confined materials have been extensively studied for photoluminescent applica- tions. Due to intrinsic limitations of low biocompatibility and challenging modulation, the utilization of conventional inorganic quantum confined photoluminescent materials in bio- imaging and bio-machine interface faces critical restrictions. Here, we present aromatic cyclo-dipeptides that dimerize into quantum dots, which serve as building blocks to further self-assemble into quantum confined supramolecular structures with diverse morphologies and photoluminescence properties. Especially, the emission can be tuned from the visible region to the near-infrared region (420 nm to 820 nm) by modulating the self-assembly process. Moreover, no obvious cytotoxic effect is observed for …


Incineration Of Nanoclay Composites Leads To Byproducts With Reduced Cellular Reactivity, Alixandra Wagner, Andrew P. White, Man Chio Tang, Sushant Agarwal, Todd A. Stueckle, Yon Rojanasakul, Rakesh K. Gupta, Carasela Zoica Dinu Jan 2018

Incineration Of Nanoclay Composites Leads To Byproducts With Reduced Cellular Reactivity, Alixandra Wagner, Andrew P. White, Man Chio Tang, Sushant Agarwal, Todd A. Stueckle, Yon Rojanasakul, Rakesh K. Gupta, Carasela Zoica Dinu

Faculty & Staff Scholarship

Addition of nanoclays into a polymer matrix leads to nanocomposites with enhanced properties to be used in plastics for food packaging applications. Because of the plastics’ high stored energy value, such nanocomposites make good candidates for disposal via municipal solid waste plants. However, upon disposal, increased concerns related to nanocomposites’ byproducts potential toxicity arise, especially considering that such byproducts could escape disposal filters to cause inhalation hazards. Herein, we investigated the effects that byproducts of a polymer polylactic acid-based nanocomposite containing a functionalized montmorillonite nanoclay (Cloisite 30B) could pose to human lung epithelial cells, used as a model for inhalation …


Graphene Nanoplatelets-Sericin Surface-Modified Gum Alloy For Improved Biological Response, Valentina Mitran, Valentina Dinca, Raluca Ion, Vasile D. Cojocaru, Patricia Neacsu, Cerasela Zoica Dinu, Laurentiu Rusen, Simona Brajnicov, Anca Bonciu, Maria Dinescu, Doina Raducanu, Ioan Dan Jan 2018

Graphene Nanoplatelets-Sericin Surface-Modified Gum Alloy For Improved Biological Response, Valentina Mitran, Valentina Dinca, Raluca Ion, Vasile D. Cojocaru, Patricia Neacsu, Cerasela Zoica Dinu, Laurentiu Rusen, Simona Brajnicov, Anca Bonciu, Maria Dinescu, Doina Raducanu, Ioan Dan

Faculty & Staff Scholarship

In this study a “Gum Metal” titanium-based alloy, Ti-31.7Nb-6.21Zr-1.4Fe-0.16O, was synthesized by melting and characterized in order to evaluate its potential for biomedical applications. The results showed that the newly developed alloy presents a very high strength, high plasticity and a low Young's modulus relative to titanium alloys currently used in medicine. For further bone implant applications, the newly synthesized alloy was surface modified with graphene nanoplatelets (GNP), sericin (SS) and graphene nanoplatelets/sericine (GNP–SS) composite films via Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. The characterization of each specimen was monitored by scanning electron microscopy (SEM), atomic force microscopy (AFM), …


Navigating The “No Man's Land” Of Tki-Failed Egfr-Mutated Non– Small Cell Lung Cancer (Nsclc): A Review, Bryan Oronsky, Patrick Ma, Tony R. Reid, Pedro Cabrales, Michelle Lybeck, Arnold Oronsky, Neil Oronsky, Corey A. Carter Jan 2018

Navigating The “No Man's Land” Of Tki-Failed Egfr-Mutated Non– Small Cell Lung Cancer (Nsclc): A Review, Bryan Oronsky, Patrick Ma, Tony R. Reid, Pedro Cabrales, Michelle Lybeck, Arnold Oronsky, Neil Oronsky, Corey A. Carter

Faculty & Staff Scholarship

As the leading cause of cancer-related mortality, lung cancer is a worldwide health issue that is overwhelmingly caused by smoking. However, a substantial minority (~25%) of patients with non–small cell lung cancer (NSCLC) has never smoked. In these patients, activating mutations of the epidermal growth factor receptor (EGFR) are more likely, which render their tumors susceptible for a finite period to treatment with EGFR tyrosine kinase inhibitors (TKIs) and confer a better prognosis than EGFR wild-type NSCLC. On progression, due to the inevitable insurgence of resistance, TKIs are generally followed by second- or third-line salvage chemotherapy until treatment failure, after …