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Full-Text Articles in Biomedical Engineering and Bioengineering
Influence Of Isoflurane On Left Atrial Function In Dogs With Pacing-Induced Cardiomyopathy: Evaluation With Pressure-Volume Relationships, Franz Kehl, John F. Ladisa, Douglas Anthony Hettrick, Judy R. Kersten, David C. Warltier, Paul S. Pagel
Influence Of Isoflurane On Left Atrial Function In Dogs With Pacing-Induced Cardiomyopathy: Evaluation With Pressure-Volume Relationships, Franz Kehl, John F. Ladisa, Douglas Anthony Hettrick, Judy R. Kersten, David C. Warltier, Paul S. Pagel
Biomedical Engineering Faculty Research and Publications
Objective
The actions of volatile anesthetics on left ventricular (LV) function in normal and failing hearts have been previously evaluated, but the effects of these agents on left atrial (LA) function in the presence of LV dysfunction are unknown. The hypothesis was tested that isoflurane alters LA mechanics evaluated with pressure-volume relations.
Design
Prospective.
Setting
Laboratory.
Participants
Barbiturate-anesthetized dogs (n = 8) were instrumented for measurement of aortic, LA, and LV pressures (micromanometers), and LA volume (epicardial orthogonal sonomicrometers) after 3 weeks of rapid ventricular pacing (220 beats/min).
Interventions
LA myocardial contractility (Ees) was assessed with end-systolic pressure-volume …