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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Reactive Oxygen Species Modulate Coronary Wall Shear Stress And Endothelial Function During Hyperglycemia, Eric R. Gross, John F. Ladisa, Dorothee Weihrauch, Lars E. Olson, Tobias T. Kress, Douglas Anthony Hettrick, Paul S. Pagel, David C. Warltier, Judy R. Kersten
Reactive Oxygen Species Modulate Coronary Wall Shear Stress And Endothelial Function During Hyperglycemia, Eric R. Gross, John F. Ladisa, Dorothee Weihrauch, Lars E. Olson, Tobias T. Kress, Douglas Anthony Hettrick, Paul S. Pagel, David C. Warltier, Judy R. Kersten
Biomedical Engineering Faculty Research and Publications
Hyperglycemia is associated with generation of reactive oxygen species (ROS), and this action may contribute to accelerated atherogenesis. We tested the hypothesis that hyperglycemia produces alterations in left anterior descending coronary artery (LAD) wall shear stress concomitant with endothelial dysfunction and ROS production in dogs (n = 12) instrumented for measurement of LAD blood flow, velocity, and diameter. Dogs were randomly assigned to receive vehicle (0.9% saline) or the superoxide dismutase mimetic 4- hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (tempol) and were administered intravenous infusions of d-glucose to achieve target blood glucose concentrations of 350 and 600 mg/dl (moderate and severe hyperglycemia, respectively). Endothelial …