Biomedical Engineering and Bioengineering Commons^™

Water Transport And The Distribution Of Aquaporin-1 In Pulmonary Air Spaces, Richard M. Effros, C. Darin, Elizabeth R. Jacobs, R. A. Rogers, Gary S. Krenz, E. E. Schneeberger

Biomedical Engineering Faculty Research and Publications

Recent evidence suggests that water transport between the pulmonary vasculature and air spaces can be inhibited by HgCl₂, an agent that inhibits water channels (aquaporin-1 and -5) of cell membranes. In the present study of isolated rat lungs, clearances of labeled (³HOH) and unlabeled water were compared after instillation of hypotonic or hypertonic solutions into the air spaces or injection of a hypotonic bolus into the pulmonary artery. The clearance of ³HOH between the air spaces and perfusate after intratracheal instillation and from the vasculature to the tissues after pulmonary arterial injections was invariably greater …