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Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
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- Bioelectrical measurement (1)
- Biopotential recording (1)
- Brain (1)
- Cell behavior (1)
- Cell morphology (1)
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- Chronic Pain (1)
- Disorder (1)
- ECM patterns (1)
- Electrode design (1)
- Electroporation (1)
- Electrotransfer (1)
- Gene delivery (1)
- Gene therapy (1)
- Guinea pig (1)
- In vivo electroporation (1)
- Microcontact printing (1)
- Monode (1)
- Multielectrode array (1)
- Neurite extension (1)
- Neuronal cell patterning (1)
- Organization of cells (1)
- Skin (1)
- Soft lithography (1)
Articles 1 - 5 of 5
Full-Text Articles in Biomedical Engineering and Bioengineering
Effect Of Extracellular Matrix (Ecm) Protein Micropatterns On The Behavior Of Human Neuroblastoma Cells, Ishwari Poudel
Effect Of Extracellular Matrix (Ecm) Protein Micropatterns On The Behavior Of Human Neuroblastoma Cells, Ishwari Poudel
Department of Engineering Mechanics: Dissertations, Theses, and Student Research
Recent advances in patterning techniques and emerging surface microtechnologies have allowed cell micropatterning to control spatial location of the cells on a surface as well as cell shape, attachment area, and number of contacting neighbor cells. These parameters play important roles in cell cellular behaviors. Cell micropatterning has thus become one of the most important strategies for biomedical applications, such as, tissue engineering, diagnostic immunoassays, lab-on-chip devices, bio-sensing, etc., and cell biology studies as well. For neuronal cells, there have been attempts to distribute neuronal cells on specific patterns to control cell-to-cell interaction. However, there have been very limited understanding …
Brain-Related Chronic Pain Disorder Diagnosis And Assessment Method, Jeffrey Hargrove
Brain-Related Chronic Pain Disorder Diagnosis And Assessment Method, Jeffrey Hargrove
Mechanical Engineering Patents
A method for diagnosing and assessing a brain-related chronic pain disorder. The method includes assessing a subject's brain function, deterrnining the probability that a subject is suffering from chronic pain as a result of an abnormal brain function condition by obtaining a quantitative assessment of the subject's brain function, and making a statistical comparison between the subject's quantitative brain function assessment and either a database of quantitative assessments of the brain functions of normal, healthy individuals, or a database of quantitative assessments of the brain functions of individuals known to have been suffering from chronic pain as a result of …
Evaluation Of Delivery Conditions For Cutaneous Plasmid Electrotransfer Using A Multielectrode Array, Bernadette Ferraro, Loree C. Heller, Yolmari L. Cruz, Siqi Guo, Amy Donate, Richard Heller
Evaluation Of Delivery Conditions For Cutaneous Plasmid Electrotransfer Using A Multielectrode Array, Bernadette Ferraro, Loree C. Heller, Yolmari L. Cruz, Siqi Guo, Amy Donate, Richard Heller
Bioelectrics Publications
Electroporation (EP) is a simple in vivo method to deliver normally impermeable molecules, such as plasmid DNA, to a variety of tissues. Delivery of plasmid DNA by EP to a large surface area is not practical because the distance between the electrode pairs, and therefore the applied voltage, must be increased to effectively permeabilize the cell membrane. The design of the multielectrode array (MEA) incorporates multiple electrode pairs at a fixed distance to allow for delivery of plasmid DNA to the skin, potentially reducing the sensation associated with in vivo EP. In this report, we evaluate the effects of field …
Novel Bioelectrical Measurement Using A Digital Biopotential Monode, Mark Nolan, Edward Burke, Eugene Coyle
Novel Bioelectrical Measurement Using A Digital Biopotential Monode, Mark Nolan, Edward Burke, Eugene Coyle
Conference Papers
In conventional biopotential recording, two or more electrodes are placed on the body. A unipolar lead records the time-varying electrical potential at a single point (relative to a reference potential) via one signal electrode. A bipolar lead records the time-varying potential difference between two points via two signal electrodes. In each case, the signal electrodes are connected to high impedance amplifier inputs, while an additional electrode provides a low-impedance path between the amplifier and human subject. Bipolar leads are usually preferred since interference appearing at both signal electrodes can be eliminated using an instrumentation amplifier with high CMRR. A drawback …
Electro-Gene Transfer To Skin Using A Noninvasive Multielectrode Array, Siqi Guo, Amy Donate, Gaurav Basu, Cathryn Lundberg, Loree Heller, Richard Heller
Electro-Gene Transfer To Skin Using A Noninvasive Multielectrode Array, Siqi Guo, Amy Donate, Gaurav Basu, Cathryn Lundberg, Loree Heller, Richard Heller
Bioelectrics Publications
Because of its large surface area and easy access for both delivery and monitoring, the skin is an attractive target for gene therapy for cutaneous diseases, vaccinations and several metabolic disorders. The critical factors for DNA delivery to the skin by electroporation (EP) are effective expression levels and minimal or no tissue damage. Here, we evaluated the non-invasive multielectrode array (MEA) for gene electrotransfer. For these studies we utilized a guinea pig model, which has been shown to have a similar thickness and structure to human skin. Our results demonstrate significantly increased gene expression 2 to 3 logs above injection …