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Full-Text Articles in Biomedical Engineering and Bioengineering
Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport
Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport
Carey Rappaport
We describe a 2-D computational model of the optical propagation in human skin from a confocal reflectance theta microscope. As an effect of decreasing the size of the microscope so that it is more clinically useful, the usual point source and detector with a raster scan is changed to a line source with a 1-D array detector. Because there is only one dimension of scanning, the microscope is confocal in one direction, but not in the other, however, this results in additional localized decreases in signal. We hypothesize that these result from the interaction of the bi-static imaging configuration with …
Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport
Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport
Charles A. DiMarzio
We describe a 2-D computational model of the optical propagation in human skin from a confocal reflectance theta microscope. As an effect of decreasing the size of the microscope so that it is more clinically useful, the usual point source and detector with a raster scan is changed to a line source with a 1-D array detector. Because there is only one dimension of scanning, the microscope is confocal in one direction, but not in the other, however, this results in additional localized decreases in signal. We hypothesize that these result from the interaction of the bi-static imaging configuration with …
Multi-Spectral Reflectance Confocal Microscopy On Skin, Tianchen Shi, Charles Dimarzio
Multi-Spectral Reflectance Confocal Microscopy On Skin, Tianchen Shi, Charles Dimarzio
Charles A. DiMarzio
Reflectance confocal microscopy is a powerful in-vivo modality for imaging superficial layers of biological tissue, especially for human skin. Three dimensional imaging capability enables confocal microscopy to resolve structures of upper skin layer cells. However, sub-celluar structure and corresponding functional organelles play more important parts in skin diseases diagnosis and monitoring. We present a new multi-spectral reflectance confocal microscopy to achieve sub-celluar functional imaging in skin by utilizing our unique Keck multi-modality microscope. Spectral information and a modified Mie scattering model are incorporated to identify distribution of melanin and mitochondria in cells. Ex-vivo and phantom experimental results are presented. Further …