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Full-Text Articles in Biomedical Engineering and Bioengineering
Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport
Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport
Carey Rappaport
We describe a 2-D computational model of the optical propagation in human skin from a confocal reflectance theta microscope. As an effect of decreasing the size of the microscope so that it is more clinically useful, the usual point source and detector with a raster scan is changed to a line source with a 1-D array detector. Because there is only one dimension of scanning, the microscope is confocal in one direction, but not in the other, however, this results in additional localized decreases in signal. We hypothesize that these result from the interaction of the bi-static imaging configuration with …
Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport
Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport
Charles A. DiMarzio
We describe a 2-D computational model of the optical propagation in human skin from a confocal reflectance theta microscope. As an effect of decreasing the size of the microscope so that it is more clinically useful, the usual point source and detector with a raster scan is changed to a line source with a 1-D array detector. Because there is only one dimension of scanning, the microscope is confocal in one direction, but not in the other, however, this results in additional localized decreases in signal. We hypothesize that these result from the interaction of the bi-static imaging configuration with …
Photo-Thermal Coherent Confocal Microscope, Sean Sullivan, Charles Dimarzio
Photo-Thermal Coherent Confocal Microscope, Sean Sullivan, Charles Dimarzio
Charles A. DiMarzio
Confocal microscopy has been shown to be useful in imaging skin slightly below the junction of the dermis and epidermis. However, the depth of imaging is a significant limitation. We present a novel concept designed both to improve the depth of penetration and to increase the information content of images obtained with a reflectance confocal microscope. Using an approach similar to optoacoustics, we plan to explore the use of laser heating to generate tissue expansion, which will be measured by the microscope. The microscope will incorporate a pulsed heating laser along the same optical path as the imaging laser in …
Compact Dual Wedge Point Scanning Confocal Reflectance Microscope, William C. Warger Ii, Stephen A. Guerrera, Charles A. Dimarzio
Compact Dual Wedge Point Scanning Confocal Reflectance Microscope, William C. Warger Ii, Stephen A. Guerrera, Charles A. Dimarzio
Charles A. DiMarzio
Confocal reflectance microscopy has been shown to provide optical sectioning and resolution sufficient to provide useful information about skin to a depth below the epidermis. However, existing instruments are large and expensive, because of the need for fast twodimensional scanning in the pupil, and the associated relay optics. A more compact scanning system could lead to an affordable hand-held instrument for in vivo imaging. Several approaches are being considered with different advantages and disadvantages. Here we report one approach that incorporates a dual-wedge scanner within a point-scanning configuration. The dual-wedge scanner is implemented by replacing the two scanning mirrors and …