Biomedical Engineering and Bioengineering Commons^™

Preliminary In Vivo Studies Of A New Injectable Bone Substitute, F. Millot, G. Grimandi, P. Weiss, G. Daculsi

Cells and Materials

Calcium-phosphate materials have been increasingly employed in orthopedic and dental applications in recent years and are now being developed for use in noninvasive surgery or as carriers for drug delivery systems. We developed an injectable bone substitute (IBS) for percutaneous orthopedic surgery which uses a biphasic calcium-phosphate (BCP) mixture composed of hydroxyapatite (60%) and ß-tricalcium phosphate (40%), together with a polymer (hydroxy-propyl-methyl-cellulose, HPMC) as a carrier. The best BCP/polymer ratio was determined to achieve the highest mineral phase in the composite and provide the rheological properties required for injectable material.

The in vivo biocompatibility and biofunctionality of IBS were …