Biomedical Engineering and Bioengineering Commons^™

Behavior Of Melanoma Cells In Cell And Organ Cultures: Use Of Biomaterials To Activate Cells, J. L. Duval, N. Faucheux, R. Warocquier-Clérout, M. D. Nagel

Cells and Materials

It is well known that cell behaviors such as adhesion, proliferation and various synthesis are initiated from transmembrane signals. This study uses biomaterials as primary messengers of the cell activation pathways, and we have analyzed the effects of two biomaterials on highly metastatic tumor cells. B16F10 melanoma cells formed heterogeneous populations whose size varied with cell differentiation. In long-term organ cultures grown comparatively on AN 69 and Cuprophan (a biomembrane known to activate cells), we found that Cuprophan increased both adhesion and proliferation of small melanin-rich cells which represented differentiated melanocyte&. In dissociated cell cultures, the rate of early cell …