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Full-Text Articles in Biomedical Engineering and Bioengineering
Simplified Meta-Analysis Of Clinical Trials In Resuscitation, Charles F. Babbs
Simplified Meta-Analysis Of Clinical Trials In Resuscitation, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Publications
Objective: To present and demonstrate a new simplified method for synthesizing results of multiple clinical trials in resuscitation research. Methods: The mean difference across studies in the proportion of favorable outcomes between experimental and control groups is calculated. This difference is shown to have a t-distribution. Its significance can be ascertained with a simple t-test. The analysis can be implemented in a one-page computer spreadsheet. Results: Simplified meta-analysis provides high sensitivity and can be extended to include weighting of studies according to size or quality, comparison of subgroups of studies, tests for outliers, and calculation of the power of the …
Interposed Abdominal Compression Cpr: A Comprehensive Evidence Based Review, Charles F. Babbs
Interposed Abdominal Compression Cpr: A Comprehensive Evidence Based Review, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Publications
Interposed abdominal compression (IAC)-CPR includes all steps of standard external CPR with the addition of manual mid-abdominal compressions in counterpoint to the rhythm of chest compressions. IAC-CPR can increase blood flow during CPR about two fold compared to standard CPR without IAC, as shown by 6 of 6 studies in computer models and 19 of 20 studies in various animal models. The addition of IAC has clinical benefit in humans, as indicated in 10 of 12 small to medium sized clinical studies. The technique increases the frequency of immediate return of spontaneous circulation for in-hospital resuscitations from roughly 25% to …