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Full-Text Articles in Biomedical Engineering and Bioengineering
Development Of Rat Head Finite Element Model And Tissue Level Biomechanical Threshold For Traumatic Axonal Injury, Runzhou Zhou
Development Of Rat Head Finite Element Model And Tissue Level Biomechanical Threshold For Traumatic Axonal Injury, Runzhou Zhou
Wayne State University Dissertations
Traumatic brain injury (TBI) is caused by local tissue deformation at the time of trauma, leading to neurological dysfunction. In the United States alone, 2.87 million people sustain a TBI each year, of which one-fifth results in death. Traumatic axonal injury (TAI) is a well-recognized consequence of every fatal head injury and more than 85% of vehicular crash-related blunt head injuries. The most common and important pathologic feature of TBIs are multifocal changes to axons in the white matter produced by rapid head acceleration/deceleration during a traumatic event with consequent local shear/tension on neural tissue and axons contributing to secondary …
Comparison Of Progression Of Diffuse Axonal Injury With Histology And Diffusion Tensor Imaging, Nisrine Zakaria
Comparison Of Progression Of Diffuse Axonal Injury With Histology And Diffusion Tensor Imaging, Nisrine Zakaria
Wayne State University Dissertations
Diffuse axonal injury, also known as traumatic axonal injury (TAI), is a major contributor to the pathology of traumatic brain injury. However, TAI is undetectable to conventional clinical magnetic resonance (MR) imaging techniques. Histologically, TAI is characterized by swollen axons that eventually disconnect and form axonal retraction balls (RB) in various white matter tracts. MR-diffusion tensor imaging (MR-DTI) has been reported to be sensitive to TAI in human TBI patients by measuring water molecular diffusion motion in white matter fiber tracts. To date, only one correlative animal study has been carried out to investigate the DTI relationship to TAI, and …