Biomedical Engineering and Bioengineering Commons^™

A Bottom-Up Assembly Of Vascularized Bioartificial Constructs Using Ecm Based Microscale Modules, Ramkumar Tiruvannamalai Annamalai

Wayne State University Dissertations

Tissue engineering aims to create functional biological tissues to treat diseases and damaged organs. A primary goal is to fabricate a 3D construct that can promote cell-cell interaction, extra cellular matrix (ECM) deposition and tissue level organization. Accomplishing these prerequisites with the currently available conventional scaffolds and fabrication techniques still remains a challenge. To reproduce the full functionality there is a need to engineer tissue constructs that mimic the innate architecture and complexity of natural tissues. The limited ability to vascularize and perfuse thick, cell-laden tissue constructs has hindered efforts to engineer complex tissues and organs, including liver, heart and …