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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Additives To Control Mechanical Properties And Drug Delivery Of Injectable Polymeric Scaffolds, Paul Fisher
Additives To Control Mechanical Properties And Drug Delivery Of Injectable Polymeric Scaffolds, Paul Fisher
Theses and Dissertations--Biomedical Engineering
In situ forming implants (ISIs) are popular due to their ease of use and local drug delivery potential, but they suffer from high initial drug burst, and release behavior is tied closely to solvent exchange and polymer properties. Additionally, such systems are traditionally viewed purely as drug delivery devices rather than potential scaffold materials due to their poor mechanical properties and minimal porosity. The aim of this research was to develop an injectable ISI with drug release, mechanical, and microstructural properties controlled by micro- and nanoparticle additives.
First, an injectable ISI was developed with appropriate drug release kinetics for orthopedic …
Growth Plate Regeneration Using Polymer-Based Scaffolds Releasing Growth Factor, Amanda Clark
Growth Plate Regeneration Using Polymer-Based Scaffolds Releasing Growth Factor, Amanda Clark
Theses and Dissertations--Biomedical Engineering
Currently growth plate fractures account for nearly 18.5% of fractures in children and can lead to stunted bone growth or angular deformation. If the body is unable to heal itself a bony bar forms, preventing normal bone growth. Clinical treatment involves removing the bony bar and replacing it with a filler substance, which causes poor results 60% of the time.
Using primarily poly(lactic-co-glycolic acid) (PLGA) as the scaffold material, the goal was to develop an implant that would support to the implant site, allow for cell ingrowth, and degrade away over time. Porous scaffolds were fabricated from PLGA microspheres using …