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Articles 1 - 5 of 5
Full-Text Articles in Biomedical Engineering and Bioengineering
Chemical And Polymer Characterization Of The Potential Modes Of Degradation Of An Injectable Nucleus Pulposus Replacement Device, Antonio G. Abbondandolo
Chemical And Polymer Characterization Of The Potential Modes Of Degradation Of An Injectable Nucleus Pulposus Replacement Device, Antonio G. Abbondandolo
Theses and Dissertations
HYDRAFIL™ is a poly(vinyl alcohol)/poly(ethylene glycol)-based hydrogel nucleus pulposus replacement device that is injected in situ and has demonstrated efficacy in lowering the prevalence and pain associated with back. In this work, we developed a method to analyze HYDRAFIL™ polymer composition using (TGA) and characterized intermolecular bonding interactions within the hydrogel through (FTIR). To function as a permanent implant for nucleus pulposus replacement, HYDRAFIL™ must be stable when exposed to a multitude of degradation pathways, namely, thermal, chemical, and mechanical. We subjected HYDRAFIL™ to accelerated thermal and chemical degradation pathways and described compositional, physical and chemical property changes using a …
Electromechanical Fatigue Properties Of Dielectric Elastomer Stretch Sensors Under Orthopaedic Loading Conditions, Andrea Karen Persons
Electromechanical Fatigue Properties Of Dielectric Elastomer Stretch Sensors Under Orthopaedic Loading Conditions, Andrea Karen Persons
Theses and Dissertations
Fatigue testing of stretch sensors often focuses on high amplitude, low-cycle fatigue (LCF) behavior; however, when used for orthopaedic, athletic, or ergonomic assessments, stretch sensors are subjected to low amplitude, high-cycle fatigue (HCF) conditions. As an added layer of complexity, the fatigue testing of stretch sensors is not only focused on the life of the material comprising the sensor, but also on the reliability of the signal produced during the extension and relaxation of the sensor. Research into the development of a smart sock that can be used to measure the range of motion (ROM) of the ankle joint during …
Enhancement Of Electrospun Nanofiber Properties Via Automated Track Post-Draw Processing, David Anthony Brennan
Enhancement Of Electrospun Nanofiber Properties Via Automated Track Post-Draw Processing, David Anthony Brennan
Theses and Dissertations
Electrospinning is an alternative manufacturing method, capable of producing fibers with nanoscale diameters from a wide range of different polymers in a process which is relatively simple and inexpensive in comparison to other forms of nanofiber production. This has made electrospinning the subject a great deal of research as a method of producing nanofibers for various high-performance applications. However, electrospun nanofiber tensile strength is weak in comparison to conventional fibers of the same material, preventing widespread use and marketization. This disparity in mechanical strength is attributed to poor polymer chain alignment in individual fibers, caused by the absence of a …
A Theoretical Study Of Polymer Based Drug Delivery Systems, Ebtisam Abdullatif Aldaais
A Theoretical Study Of Polymer Based Drug Delivery Systems, Ebtisam Abdullatif Aldaais
Theses and Dissertations
Polymer nanostructured materials for drug delivery applications have witnessed tremendous progress in recent years due to their vast potential. One-end-grafted polymers can form grafted micelles with specific mechanical properties. Biological conditions can alter these properties resulting in the protection or release of drugs. Charged surfactants can also form micelles in an aqueous solution, which can also be manipulated through special conditions. On the micellar surface, self-organized polyelectrolytes can be stimulated to extend their attached ligands and thus increase the probability of binding to targeted receptors. This thesis focuses on modeling polymer-based drug delivery systems by studying the physical interactions between …
Novel Apparatus To Control Electrospinning Fiber Orientation For The Production Of Tissue Engineering Scaffolds, Eugene David Boland
Novel Apparatus To Control Electrospinning Fiber Orientation For The Production Of Tissue Engineering Scaffolds, Eugene David Boland
Theses and Dissertations
The conception of electrospinning can trace its roots back more than 400 years, when it was observed that rubbed amber can deform a droplet of water on a smooth surface, and is based upon simple concepts of charge separation and surface tension. Since that time, considerable effort has been directed at both the cause and utility of this phenomenon. The specific aim of this dissertation project was to develop an automated electrostatic processing apparatus that was capable of controlling the three-dimensional architecture of an electrospun scaffold to further improve its utility in tissue engineering. The efficacy of using this technique …